3-hydroxyisobutyryl-CoA hydrolase
Class of enzymes
3-hydroxyisobutyryl-CoA hydrolase | |||||||||
---|---|---|---|---|---|---|---|---|---|
3-hydroxyisobutyryl-CoA hydrolase monomer, Human | |||||||||
Identifiers | |||||||||
EC no. | 3.1.2.4 | ||||||||
CAS no. | 9025-88-1 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
|
The enzyme 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) catalyzes the reaction
- 3-hydroxy-2-methylpropanoyl-CoA + H2O CoA + 3-hydroxy-2-methylpropanoate
This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name is 3-hydroxy-2-methylpropanoyl-CoA hydrolase. Other names in common use include 3-hydroxy-isobutyryl CoA hydrolase, and HIB CoA deacylase. This enzyme participates in 3 metabolic pathways: valine, leucine and isoleucine degradation, β-alanine metabolism, and propanoate metabolism. 3-hydroxyisobutyryl-CoA hydrolase is encoded by HIBCH gene.[1]
References
- ^ "OMIM Entry - * 610690 - 3-HYDROXYISOBUTYRYL-CoA HYDROLASE; HIBCH". www.omim.org. Retrieved 2017-11-20.
- Rendina G, Coon MJ (March 1957). "Enzymatic hydrolysis of the coenzyme A thiol esters of β-hydroxypropionic and β-hydroxyisobutyric acids". The Journal of Biological Chemistry. 225 (1): 523–34. PMID 13457352.
- v
- t
- e
ester hydrolases
- Alkaline phosphatase
- Acid phosphatase (Prostatic)/Tartrate-resistant acid phosphatase/Purple acid phosphatases
- Nucleotidase
- Glucose 6-phosphatase
- Fructose 1,6-bisphosphatase
- Protein phosphatase
- OCRL
- Pyruvate dehydrogenase phosphatase
- Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase
- PTEN
- Phytase
- Inositol-phosphate phosphatase
- Protein phosphatase: Protein tyrosine phosphatase
- Protein serine/threonine phosphatase
- Dual-specificity phosphatase
Phosphodiesterase
deoxyribonuclease
and ribonuclease)
3.1.11-16: Exonuclease |
| ||||||
---|---|---|---|---|---|---|---|
3.1.21-31: Endonuclease |
|