ADAM8 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | ADAM8, CD156, CD156a, MS2, ADAM metallopeptidase domain 8 |
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External IDs | OMIM: 602267; MGI: 107825; HomoloGene: 74384; GeneCards: ADAM8; OMA:ADAM8 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 10 (human)[1] |
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| Band | 10q26.3 | Start | 133,262,420 bp[1] |
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End | 133,276,868 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 7 (mouse)[2] |
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| Band | 7|7 F4 | Start | 139,558,845 bp[2] |
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End | 139,572,475 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - granulocyte
- blood
- spleen
- monocyte
- bone marrow cells
- pancreatic ductal cell
- periodontal fiber
- appendix
- upper lobe of left lung
- right lung
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| Top expressed in | - granulocyte
- stroma of bone marrow
- decidua
- trachea
- calvaria
- tibiofemoral joint
- lumbar spinal ganglion
- gastrula
- vein
- mesenteric lymph nodes
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| More reference expression data |
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BioGPS |
| More reference expression data |
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Gene ontology |
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Molecular function | - metal ion binding
- protein self-association
- peptidase activity
- protein binding
- metalloendopeptidase activity
- hydrolase activity
- cell adhesion molecule binding
- calcium ion binding
- serine-type endopeptidase activity
- metallopeptidase activity
- zinc ion binding
| Cellular component | - cytoplasm
- integral component of membrane
- alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex
- membrane
- tertiary granule
- integral component of plasma membrane
- cell surface
- specific granule
- dense core granule membrane
- podosome
- phagolysosome
- alpha9-beta1 integrin-ADAM8 complex
- plasma membrane
- specific granule membrane
- tertiary granule membrane
- ficolin-1-rich granule membrane
| Biological process | - positive regulation of inflammatory response
- extracellular matrix disassembly
- proteolysis
- positive regulation of cellular extravasation
- positive regulation of neutrophil extravasation
- positive regulation of protein processing
- regulation of cell-cell adhesion
- positive regulation of protein secretion
- inflammatory response
- cellular response to hypoxia
- positive regulation of T cell migration
- positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
- positive regulation of acute inflammatory response
- cell morphogenesis
- positive regulation of thymocyte apoptotic process
- positive regulation of bone resorption
- negative regulation of neuron apoptotic process
- positive regulation of fibronectin-dependent thymocyte migration
- positive regulation of eosinophil migration
- positive regulation of NF-kappaB transcription factor activity
- leukocyte migration involved in inflammatory response
- positive regulation of membrane protein ectodomain proteolysis
- positive regulation of protein kinase B signaling
- positive regulation of T cell differentiation in thymus
- lymphocyte chemotaxis
- positive regulation of cell adhesion
- angiogenesis
- neutrophil degranulation
- cell-cell adhesion
- positive regulation of MAP kinase activity
- positive regulation of innate immune response
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001109 NM_001164489 NM_001164490 |
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RefSeq (protein) | |
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NP_001100 NP_001157961 NP_001157962 |
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Location (UCSC) | Chr 10: 133.26 – 133.28 Mb | Chr 7: 139.56 – 139.57 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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