ARHGEF4 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/6/6f/Protein_ARHGEF4_PDB_2dx1.png/250px-Protein_ARHGEF4_PDB_2dx1.png) |
Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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2DX1, 2PZ1, 3NMX, 3NMZ |
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Identifiers |
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Aliases | ARHGEF4, ASEF, ASEF1, GEF4, STM6, Rho guanine nucleotide exchange factor 4, SMIM39 |
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External IDs | OMIM: 605216; MGI: 2442507; HomoloGene: 49414; GeneCards: ARHGEF4; OMA:ARHGEF4 - orthologs |
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Gene location (Human) |
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![Chromosome 2 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Ideogram_human_chromosome_2.svg/300px-Ideogram_human_chromosome_2.svg.png) | Chr. | Chromosome 2 (human)[1] |
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| Band | 2q21.1 | Start | 130,836,914 bp[1] |
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End | 131,047,263 bp[1] |
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Gene location (Mouse) |
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![Chromosome 1 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Ideogram_house_mouse_chromosome_1.svg/260px-Ideogram_house_mouse_chromosome_1.svg.png) | Chr. | Chromosome 1 (mouse)[2] |
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| Band | 1|1 B | Start | 34,678,188 bp[2] |
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End | 34,813,309 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - right frontal lobe
- nucleus accumbens
- prefrontal cortex
- Brodmann area 9
- cingulate gyrus
- anterior cingulate cortex
- amygdala
- putamen
- caudate nucleus
- Brodmann area 10
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| Top expressed in | - central gray substance of midbrain
- pontine nuclei
- dorsal tegmental nucleus
- anterior horn of spinal cord
- medial vestibular nucleus
- superior colliculus
- hippocampus proper
- dentate gyrus
- facial motor nucleus
- nucleus of stria terminalis
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/6/66/PBB_GE_ARHGEF4_205109_s_at_fs.png/250px-PBB_GE_ARHGEF4_205109_s_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/7/72/PBB_GE_ARHGEF4_211891_s_at_fs.png/250px-PBB_GE_ARHGEF4_211891_s_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - protein binding
- protein domain specific binding
- guanyl-nucleotide exchange factor activity
| Cellular component | - cytoplasm
- ruffle membrane
- cytosol
- plasma membrane
- cell projection
- membrane
| Biological process | - filopodium assembly
- regulation of Rho protein signal transduction
- intracellular signal transduction
- regulation of small GTPase mediated signal transduction
- lamellipodium assembly
- positive regulation of apoptotic process
- G protein-coupled receptor signaling pathway
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | NM_015320 NM_032995 NM_001367493 NM_001375900 NM_001375901
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NM_001375902 NM_001375903 NM_001375904 NM_001395416 |
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RefSeq (protein) | NP_056135 NP_001354422 NP_001362829 NP_001362830 NP_001362831
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NP_001362832 NP_001362833 |
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Location (UCSC) | Chr 2: 130.84 – 131.05 Mb | Chr 1: 34.68 – 34.81 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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