Adenophostin
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IUPAC name [(2R,3R,4R,5R)-2-(6-Amino-9-purinyl)-4-[[(2R,3R,4R,5R,6R)-3-hydroxy-6-(hydroxymethyl)-4,5-diphosphonooxy-2-tetrahydropyranyl]oxy]-5-(hydroxymethyl)-3-tetrahydrofuranyl] dihydrogen phosphate | |
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Chemical formula | C16H26N5O18P3 |
Molar mass | 669.32 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ![]() ![]() ![]() Infobox references |
Chemical compound
Adenophostin A is a potent inositol trisphosphate (IP3) receptor agonist, but is much more potent than IP3.
IP3R is a ligand-gated intracellular Ca2+ release channel that plays a central role in modulating cytoplasmic free Ca2+ concentration (Ca2+i). Adenophostin A is structurally different from IP3 but could elicit distinct calcium signals in cells.[1]
References
- ^ Mak, D.-O. D.; McBride, S; Foskett, JK (2001). "ATP-dependent Adenophostin Activation of Inositol 1,4,5-Trisphosphate Receptor Channel Gating: Kinetic Implications for the Durations of Calcium Puffs in Cells". The Journal of General Physiology. 117 (4): 299–314. doi:10.1085/jgp.117.4.299. PMC 2217258. PMID 11279251.
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