Autophagy-related protein 13

Protein-coding gene in the species Homo sapiens

ATG13
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

5C50

Identifiers
AliasesATG13, KIAA0652, PARATARG8, autophagy related 13
External IDsOMIM: 615088; MGI: 1196429; HomoloGene: 32229; GeneCards: ATG13; OMA:ATG13 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for ATG13
Genomic location for ATG13
Band11p11.2Start46,617,527 bp[1]
End46,674,818 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for ATG13
Genomic location for ATG13
Band2|2 E1Start91,504,963 bp[2]
End91,540,921 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • right testis

  • anterior pituitary

  • epithelium of colon

  • prefrontal cortex

  • right frontal lobe

  • skin of leg

  • tibial nerve

  • right hemisphere of cerebellum

  • body of pancreas
Top expressed in
  • neural layer of retina

  • superior frontal gyrus

  • muscle of thigh

  • dentate gyrus of hippocampal formation granule cell

  • primary visual cortex

  • lip

  • blastocyst

  • cerebellar cortex

  • epithelium of lens

  • esophagus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • protein kinase binding
Cellular component
  • cytoplasm
  • cytosol
  • Atg1/ULK1 kinase complex
  • mitochondrion
  • phagophore assembly site
  • endoplasmic reticulum membrane
Biological process
  • autophagy
  • macroautophagy
  • autophagosome assembly
  • positive regulation of protein targeting to mitochondrion
  • mitophagy
  • response to mitochondrial depolarisation
  • regulation of macroautophagy
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9776

51897

Ensembl

ENSG00000175224

ENSMUSG00000027244

UniProt

O75143

Q91YI1

RefSeq (mRNA)
NM_001142673
NM_001205119
NM_001205120
NM_001205121
NM_001205122

NM_001346311
NM_001346312
NM_001346313
NM_001346314
NM_001346315
NM_001346316
NM_001346317
NM_001346318
NM_001346319
NM_001346320
NM_001346321
NM_001346322
NM_001346323
NM_001346324
NM_001346325
NM_001346326
NM_001346327
NM_001346328
NM_001346329
NM_001346330
NM_001346331
NM_001346332
NM_001346333
NM_001346334
NM_001346335
NM_001346336
NM_001346337
NM_001346338
NM_001346340
NM_001346342
NM_001346344
NM_001346346
NM_001346348
NM_001346349
NM_001346350
NM_001346351
NM_001346352
NM_001346353
NM_001346354
NM_001346355
NM_001346356
NM_001346357
NM_001346358
NM_001346359
NM_001346360
NM_014741

NM_145528
NM_001355416
NM_001355417
NM_001355418
NM_001355419

NM_001355420
NM_001355421

RefSeq (protein)
NP_001136145
NP_001192048
NP_001192049
NP_001192050
NP_001192051

NP_001333240
NP_001333241
NP_001333242
NP_001333243
NP_001333244
NP_001333245
NP_001333246
NP_001333247
NP_001333248
NP_001333249
NP_001333250
NP_001333251
NP_001333252
NP_001333253
NP_001333254
NP_001333255
NP_001333256
NP_001333257
NP_001333258
NP_001333259
NP_001333260
NP_001333261
NP_001333262
NP_001333263
NP_001333264
NP_001333265
NP_001333266
NP_001333267
NP_001333269
NP_001333271
NP_001333273
NP_001333275
NP_001333277
NP_001333278
NP_001333279
NP_001333280
NP_001333281
NP_001333282
NP_001333283
NP_001333284
NP_001333285
NP_001333286
NP_001333287
NP_001333288
NP_001333289
NP_055556

NP_663503
NP_001342345
NP_001342346
NP_001342347
NP_001342348

NP_001342349
NP_001342350

Location (UCSC)Chr 11: 46.62 – 46.67 MbChr 2: 91.5 – 91.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Autophagy-related protein 13 also known as ATG13 is a protein that in humans is encoded by the KIAA0652 gene.[5]

ATG13 is an autophagy factor required for phagosome formation. ATG13 is a target of the TOR kinase signaling pathway that regulates autophagy through phosphorylation of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex.[6][7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175224 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027244 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: KIAA0652".
  6. ^ Mercer CA, Kaliappan A, Dennis PB (July 2009). "A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy". Autophagy. 5 (5): 649–62. doi:10.4161/auto.5.5.8249. PMID 19287211.
  7. ^ Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y, Iemura S, Natsume T, Takehana K, Yamada N, Guan JL, Oshiro N, Mizushima N (April 2009). "Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy". Mol. Biol. Cell. 20 (7): 1981–91. doi:10.1091/mbc.E08-12-1248. PMC 2663915. PMID 19211835.
  8. ^ Chan EY, Longatti A, McKnight NC, Tooze SA (January 2009). "Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism". Mol. Cell. Biol. 29 (1): 157–71. doi:10.1128/MCB.01082-08. PMC 2612494. PMID 18936157.

Further reading

  • Hosokawa N, Sasaki T, Iemura S, et al. (2009). "Atg101, a novel mammalian autophagy protein interacting with Atg13". Autophagy. 5 (7): 973–9. doi:10.4161/auto.5.7.9296. PMID 19597335.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Chan EY (2009). "mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex". Science Signaling. 2 (84): pe51. doi:10.1126/scisignal.284pe51. PMID 19690328. S2CID 206673207.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Jung CH, Jun CB, Ro SH, et al. (2009). "ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery". Mol. Biol. Cell. 20 (7): 1992–2003. doi:10.1091/mbc.E08-12-1249. PMC 2663920. PMID 19225151.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  • Chan EY, Longatti A, McKnight NC, Tooze SA (2009). "Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism". Mol. Cell. Biol. 29 (1): 157–71. doi:10.1128/MCB.01082-08. PMC 2612494. PMID 18936157.
  • Ganley IG, Lam du H, Wang J, et al. (2009). "ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy". J. Biol. Chem. 284 (18): 12297–305. doi:10.1074/jbc.M900573200. PMC 2673298. PMID 19258318.
  • Sinzelle L, Kapitonov VV, Grzela DP, et al. (2008). "Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes". Proc. Natl. Acad. Sci. U.S.A. 105 (12): 4715–20. Bibcode:2008PNAS..105.4715S. doi:10.1073/pnas.0707746105. PMC 2290759. PMID 18339812.


  • v
  • t
  • e