CCDC80

Protein-coding gene in humans
CCDC80
Identifiers
AliasesCCDC80, DRO1, SSG1, URB, okuribin, coiled-coil domain containing 80, CL2, LINC01279
External IDsOMIM: 608298; MGI: 1915146; HomoloGene: 12206; GeneCards: CCDC80; OMA:CCDC80 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for CCDC80
Genomic location for CCDC80
Band3q13.2Start112,596,797 bp[1]
End112,649,530 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for CCDC80
Genomic location for CCDC80
Band16|16 B5Start44,913,765 bp[2]
End44,948,440 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • parietal pleura

  • tendon of biceps brachii

  • smooth muscle tissue

  • skin of arm

  • gallbladder

  • skin of hip

  • vena cava

  • saphenous vein

  • stromal cell of endometrium

  • tibia
Top expressed in
  • calvaria

  • stroma of bone marrow

  • white adipose tissue

  • ankle

  • skin of external ear

  • body of femur

  • semi-lunar valve

  • efferent ductule

  • aortic valve

  • belly cord
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • fibronectin binding
  • glycosaminoglycan binding
  • heparin binding
Cellular component
  • extracellular region
  • basement membrane
  • interstitial matrix
  • extracellular matrix
Biological process
  • extracellular matrix organization
  • positive regulation of cell-substrate adhesion
  • response to bacterium
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

151887

67896

Ensembl

ENSG00000091986

ENSMUSG00000022665

UniProt

Q76M96

Q8R2G6

RefSeq (mRNA)

NM_199512
NM_199511
NM_178274

NM_026439

RefSeq (protein)

NP_955805
NP_955806

NP_080715

Location (UCSC)Chr 3: 112.6 – 112.65 MbChr 16: 44.91 – 44.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Coiled-coil domain-containing protein 80 is a protein that in humans is encoded by the CCDC80 gene.[5][6][7] Bioinformatics analysis suggests the CCDC80 protein is a peroxiredoxin.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000091986 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022665 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bonaldo MF, Lennon G, Soares MB (May 1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  6. ^ Liu Y, Monticone M, Tonachini L, Mastrogiacomo M, Marigo V, Cancedda R, Castagnola P (Aug 2004). "URB expression in human bone marrow stromal cells and during mouse development". Biochem Biophys Res Commun. 322 (2): 497–507. doi:10.1016/j.bbrc.2004.07.161. PMID 15325258.
  7. ^ "Entrez Gene: CCDC80 coiled-coil domain containing 80".
  8. ^ Pawłowski K, Muszewska A, Lenart A, et al. (2010). "A widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins". BMC Genomics. 11: 590. doi:10.1186/1471-2164-11-590. PMC 3091736. PMID 20964819.

Further reading

  • Okada T, Nishizawa H, Kurata A, et al. (2008). "URB is abundantly expressed in adipose tissue and dysregulated in obesity". Biochem. Biophys. Res. Commun. 367 (2): 370–6. doi:10.1016/j.bbrc.2007.12.164. PMID 18178152.
  • Cha SY, Sung YK, Im S, et al. (2005). "URB expression in human dermal papilla cells". J. Dermatol. Sci. 39 (2): 128–30. doi:10.1016/j.jdermsci.2005.05.005. PMID 15998583.
  • Bommer GT, Jäger C, Dürr EM, et al. (2005). "DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells". J. Biol. Chem. 280 (9): 7962–75. doi:10.1074/jbc.M412593200. PMID 15563452.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Aoki K, Sun YJ, Aoki S, et al. (2002). "Cloning, expression, and mapping of a gene that is upregulated in adipose tissue of mice deficient in bombesin receptor subtype-3". Biochem. Biophys. Res. Commun. 290 (4): 1282–8. doi:10.1006/bbrc.2002.6337. PMID 11812002.


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