CD2BP2

Protein-coding gene in the species Homo sapiens
CD2BP2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1GYF, 1L2Z, 1SYX, 4BWS

Identifiers
AliasesCD2BP2, FWP010, LIN1, PPP1R59, Snu40, U5-52K, CD2 (cytoplasmic tail) binding protein 2, CD2 cytoplasmic tail binding protein 2
External IDsOMIM: 604470; MGI: 1917483; HomoloGene: 4455; GeneCards: CD2BP2; OMA:CD2BP2 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for CD2BP2
Genomic location for CD2BP2
Band16p11.2Start30,350,773 bp[1]
End30,355,308 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for CD2BP2
Genomic location for CD2BP2
Band7|7 F3Start126,790,832 bp[2]
End126,795,222 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tendon of biceps brachii

  • granulocyte

  • left adrenal gland

  • left adrenal cortex

  • right adrenal gland

  • right adrenal cortex

  • islet of Langerhans

  • beta cell

  • left uterine tube

  • gastric mucosa
Top expressed in
  • saccule

  • otic placode

  • otic vesicle

  • ventricular zone

  • dentate gyrus of hippocampal formation granule cell

  • neural layer of retina

  • ganglionic eminence

  • granulocyte

  • epiblast

  • superior cervical ganglion
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • ribonucleoprotein complex binding
  • protein binding
Cellular component
  • U5 snRNP
  • nuclear speck
  • U4/U6 x U5 tri-snRNP complex
  • nucleus
  • nucleoplasm
  • fibrillar center
  • cytoplasm
  • cytosol
Biological process
  • negative regulation of phosphatase activity
  • mRNA splicing, via spliceosome
  • mRNA processing
  • spliceosomal tri-snRNP complex assembly
  • RNA splicing
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10421

70233

Ensembl

ENSG00000169217

ENSMUSG00000042502

UniProt

O95400

Q9CWK3

RefSeq (mRNA)

NM_006110
NM_001243646

NM_001285905
NM_001285906
NM_001285907
NM_027353
NM_001357817

RefSeq (protein)

NP_001230575
NP_006101
NP_001230575.1
NP_006101.1

NP_001272834
NP_001272835
NP_001272836
NP_081629
NP_001344746

Location (UCSC)Chr 16: 30.35 – 30.36 MbChr 7: 126.79 – 126.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CD2 antigen cytoplasmic tail-binding protein 2 is a protein that in humans is encoded by the CD2BP2 gene.[5][6]


Interactions

CD2BP2 has been shown to interact with CD2.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169217 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042502 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Nishizawa K, Freund C, Li J, Wagner G, Reinherz EL (Jan 1999). "Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation". Proc Natl Acad Sci U S A. 95 (25): 14897–902. doi:10.1073/pnas.95.25.14897. PMC 24547. PMID 9843987.
  6. ^ "Entrez Gene: CD2BP2 CD2 (cytoplasmic tail) binding protein 2".

Further reading

  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Laggerbauer B, Liu S, Makarov E, et al. (2005). "The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation". RNA. 11 (5): 598–608. doi:10.1261/rna.2300805. PMC 1370748. PMID 15840814.
  • Cohavy O, Zhou J, Ware CF, Targan SR (2005). "LIGHT is constitutively expressed on T and NK cells in the human gut and can be induced by CD2-mediated signaling". J. Immunol. 174 (2): 646–53. doi:10.4049/jimmunol.174.2.646. PMID 15634882.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kofler M, Heuer K, Zech T, Freund C (2004). "Recognition sequences for the GYF domain reveal a possible spliceosomal function of CD2BP2". J. Biol. Chem. 279 (27): 28292–7. doi:10.1074/jbc.M402008200. PMID 15105431.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Freund C, Kühne R, Yang H, et al. (2003). "Dynamic interaction of CD2 with the GYF and the SH3 domain of compartmentalized effector molecules". EMBO J. 21 (22): 5985–95. doi:10.1093/emboj/cdf602. PMC 137194. PMID 12426371.
  • Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
  • Freund C, Dötsch V, Nishizawa K, et al. (1999). "The GYF domain is a novel structural fold that is involved in lymphoid signaling through proline-rich sequences". Nat. Struct. Biol. 6 (7): 656–60. doi:10.1038/10712. PMID 10404223. S2CID 19688996.
  • v
  • t
  • e
  • 1gyf: GYF DOMAIN FROM HUMAN CD2BP2 PROTEIN
    1gyf: GYF DOMAIN FROM HUMAN CD2BP2 PROTEIN
  • 1l2z: CD2BP2-GYF domain in complex with proline-rich CD2 tail segment peptide
    1l2z: CD2BP2-GYF domain in complex with proline-rich CD2 tail segment peptide
  • 1syx: The crystal structure of a binary U5 snRNP complex
    1syx: The crystal structure of a binary U5 snRNP complex


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