CLDN22

Protein-coding gene in the species Homo sapiens
CLDN22
Identifiers
AliasesCLDN22, CLDN21, claudin 22
External IDsMGI: 1922927; HomoloGene: 129823; GeneCards: CLDN22; OMA:CLDN22 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for CLDN22
Genomic location for CLDN22
Band4q35.1Start183,318,100 bp[1]
End183,320,276 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for CLDN22
Genomic location for CLDN22
Band8|8 B1.1Start48,277,517 bp[2]
End48,278,511 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • olfactory zone of nasal mucosa

  • minor salivary glands

  • gonad

  • granulocyte

  • right lobe of liver

  • apex of heart

  • primary visual cortex

  • endometrium

  • ventricular zone
Top expressed in
  • parotid gland

  • sciatic nerve

  • otolith organ

  • utricle

  • lacrimal gland

  • vestibular sensory epithelium

  • blastocyst

  • morula

  • lumbar spinal ganglion

  • vestibular membrane of cochlear duct
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • structural molecule activity
  • identical protein binding
Cellular component
  • plasma membrane
  • integral component of membrane
  • cell junction
  • membrane
  • bicellular tight junction
Biological process
  • calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

53842

75677

Ensembl

ENSG00000177300

ENSMUSG00000038064

UniProt

Q8N7P3

Q9D7U6

RefSeq (mRNA)

NM_001111319

NM_029383

RefSeq (protein)

NP_001104789

NP_083659

Location (UCSC)Chr 4: 183.32 – 183.32 MbChr 8: 48.28 – 48.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Claudin-22 is a protein that in humans is encoded by the CLDN22 gene.[5] It belongs to the group of claudins.


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177300 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038064 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CLDN22 claudin 22".

Further reading

  • González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
  • Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
  • Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726. S2CID 36524601.
  • Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307. S2CID 12132159.
  • Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502. S2CID 26473781.
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Katoh M, Katoh M (2004). "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family". Int. J. Mol. Med. 11 (6): 683–9. doi:10.3892/ijmm.11.6.683. PMID 12736707.
  • Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC 4777318. PMID 26680015.


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