CLDN8

Protein-coding gene in the species Homo sapiens

CLDN8

Identifiers

Aliases

CLDN8, HEL-S-79, claudin 8

External IDs

OMIM: 611231; MGI: 1859286; HomoloGene: 8117; GeneCards: CLDN8; OMA:CLDN8 - orthologs

Gene location (Human)

Chr.	Chromosome 21 (human)^[1]

Band	21q22.11	Start	30,214,006 bp^[1]
Band	21q22.11	End	30,216,097 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)^[2]

Band	16\|16 C3.3	Start	88,357,716 bp^[2]
Band	16\|16 C3.3	End	88,360,071 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

mucosa of sigmoid colon

kidney tubule

parotid gland

rectum

renal medulla

bronchial epithelial cell

human kidney

hair follicle

skin of thigh

seminal vesicula

Top expressed in

seminal vesicula

transitional epithelium of urinary bladder

vestibular membrane of cochlear duct

vestibular sensory epithelium

left colon

right kidney

submandibular gland

parotid gland

medullary collecting duct

stria vascularis

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	structural molecule activity protein binding identical protein binding
Cellular component	membrane cell junction basolateral plasma membrane integral component of membrane apicolateral plasma membrane endoplasmic reticulum plasma membrane bicellular tight junction
Biological process	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9073


54420

Ensembl


ENSG00000156284


ENSMUSG00000050520

UniProt


P56748


Q9Z260

RefSeq (mRNA)


NM_199328 NM_012132


NM_018778

RefSeq (protein)


NP_955360


NP_061248

Location (UCSC)

Chr 21: 30.21 – 30.22 Mb

Chr 16: 88.36 – 88.36 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Claudin-8 is a protein that in humans is encoded by the CLDN8 gene.^[5]^[6] It belongs to the group of claudins.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000156284 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050520 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Morita K, Furuse M, Fujimoto K, Tsukita S (Mar 1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands". Proc Natl Acad Sci U S A. 96 (2): 511–6. Bibcode:1999PNAS...96..511M. doi:10.1073/pnas.96.2.511. PMC 15167. PMID 9892664.
^ "Entrez Gene: CLDN8 claudin 8".

External links

Human CLDN8 genome location and CLDN8 gene details page in the UCSC Genome Browser.

Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502. S2CID 26473781.
Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307. S2CID 12132159.
Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726. S2CID 36524601.
Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Itoh M, Furuse M, Morita K, et al. (2000). "Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins". J. Cell Biol. 147 (6): 1351–63. doi:10.1083/jcb.147.6.1351. PMC 2168087. PMID 10601346.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
Brandner JM, Kief S, Grund C, et al. (2003). "Organization and formation of the tight junction system in human epidermis and cultured keratinocytes". Eur. J. Cell Biol. 81 (5): 253–63. doi:10.1078/0171-9335-00244. PMID 12067061.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Katoh M, Katoh M (2004). "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family". Int. J. Mol. Med. 11 (6): 683–9. doi:10.3892/ijmm.11.6.683. PMID 12736707.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC 4777318. PMID 26680015.