CPNE4

Protein-coding gene in humans
CPNE4
Identifiers
AliasesCPNE4, COPN4, CPN4, copine 4
External IDsOMIM: 604208; MGI: 1921270; HomoloGene: 26078; GeneCards: CPNE4; OMA:CPNE4 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for CPNE4
Genomic location for CPNE4
Band3q22.1Start131,533,555 bp[1]
End132,285,410 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for CPNE4
Genomic location for CPNE4
Band9|9 F1Start104,424,485 bp[2]
End104,911,743 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • lateral nuclear group of thalamus

  • myocardium of left ventricle

  • endothelial cell

  • primary visual cortex

  • Brodmann area 23

  • palpebral conjunctiva

  • dorsolateral prefrontal cortex

  • Brodmann area 9

  • Brodmann area 46

  • right ventricle
Top expressed in
  • dentate gyrus of hippocampal formation granule cell

  • lumbar spinal ganglion

  • hippocampus proper

  • trigeminal ganglion

  • primary visual cortex

  • habenula

  • superior frontal gyrus

  • olfactory bulb

  • temporal lobe

  • glossopharyngeal ganglion
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • calcium-dependent phospholipid binding
Cellular component
  • extracellular exosome
  • plasma membrane
Biological process
  • cellular response to calcium ion
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

131034

74020

Ensembl

ENSG00000196353

ENSMUSG00000032564

UniProt

Q96A23
Q4G168

Q8BLR2

RefSeq (mRNA)

NM_001289112
NM_130808
NM_153429
NM_001388326
NM_001388327

NM_028719
NM_001357439
NM_001378996

RefSeq (protein)
NP_001276041
NP_570720
NP_702907
NP_001276041.1
NP_570720.1

NP_702907.1

NP_082995
NP_001344368
NP_001365925

Location (UCSC)Chr 3: 131.53 – 132.29 MbChr 9: 104.42 – 104.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Copine-4 is a protein that in humans is encoded by the CPNE4 gene.[5][6][7]

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm.

This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196353 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032564 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Creutz CE, Tomsig JL, Snyder SL, Gautier MC, Skouri F, Beisson J, Cohen J (Feb 1998). "The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans". J Biol Chem. 273 (3): 1393–402. doi:10.1074/jbc.273.3.1393. PMID 9430674.
  6. ^ Maitra R, Grigoryev DN, Bera TK, Pastan IH, Lee B (Apr 2003). "Cloning, molecular characterization, and expression analysis of Copine 8". Biochem Biophys Res Commun. 303 (3): 842–7. doi:10.1016/S0006-291X(03)00445-5. PMID 12670487.
  7. ^ a b "Entrez Gene: CPNE4 copine IV".

Further reading

  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Tomsig JL, Snyder SL, Creutz CE (2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif". J. Biol. Chem. 278 (12): 10048–54. doi:10.1074/jbc.M212632200. PMID 12522145.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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