CST2

Protein-coding gene in the species Homo sapiens

CST2

Identifiers

Aliases

CST2, cystatin SA

External IDs

OMIM: 123856; GeneCards: CST2; OMA:CST2 - orthologs

Gene location (Human)

Chr.	Chromosome 20 (human)^[1]

Band	20p11.21	Start	23,823,769 bp^[1]
Band	20p11.21	End	23,826,729 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

parotid gland

decidua

tongue

seminal vesicula

thalamus

thymus

right adrenal cortex

gallbladder

olfactory zone of nasal mucosa

gonad

n/a

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	peptidase inhibitor activity protein binding protease binding cysteine-type endopeptidase inhibitor activity
Cellular component	extracellular region extracellular space
Biological process	negative regulation of peptidase activity detection of chemical stimulus involved in sensory perception of bitter taste negative regulation of cysteine-type endopeptidase activity negative regulation of endopeptidase activity
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1470


n/a

Ensembl


ENSG00000170369


n/a

UniProt


P09228


n/a

RefSeq (mRNA)


NM_001322


n/a

RefSeq (protein)


NP_001313


n/a

Location (UCSC)

Chr 20: 23.82 – 23.83 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Cystatin-SA is a protein that in humans is encoded by the CST2 gene.^[3]

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted thiol protease inhibitor found at high levels in saliva, tears and seminal plasma.^[3]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170369 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CST2 cystatin SA".

External links

The MEROPS online database for peptidases and their inhibitors: I25.009
Human CST2 genome location and CST2 gene details page in the UCSC Genome Browser.

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Abrahamson M, Jonsdottir S, Olafsson I, et al. (1992). "Hereditary cystatin C amyloid angiopathy: identification of the disease-causing mutation and specific diagnosis by polymerase chain reaction based analysis". Hum. Genet. 89 (4): 377–80. doi:10.1007/BF00194306. PMID 1352269. S2CID 24226058.
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Abrahamson M, Grubb A, Olafsson I, Lundwall A (1987). "Molecular cloning and sequence analysis of cDNA coding for the precursor of the human cysteine proteinase inhibitor cystatin C". FEBS Lett. 216 (2): 229–33. doi:10.1016/0014-5793(87)80695-6. PMID 3495457. S2CID 27976400.
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Janowski R, Kozak M, Jankowska E, et al. (2001). "Human cystatin C, an amyloidogenic protein, dimerizes through three-dimensional domain swapping" (PDF). Nat. Struct. Biol. 8 (4): 316–20. doi:10.1038/86188. PMID 11276250. S2CID 28916747.