CX157
Chemical compound
- none
- In general: uncontrolled
- 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiine 10,10-dioxide
- 205187-53-7 Y
- 18687754
- 13701383 Y
- O6L62LZJ0Q
- DTXSID40174517
- Interactive image
- FC(F)(F)COc2cc3Oc1cc(F)ccc1S(=O)(=O)c3cc2
InChI
- InChI=1S/C14H8F4O4S/c15-8-1-3-12-10(5-8)22-11-6-9(21-7-14(16,17)18)2-4-13(11)23(12,19)20/h1-6H,7H2 Y
- Key:PDIMOTRDGUQMNY-UHFFFAOYSA-N Y
CX157 (proposed trade name TriRima, formerly Tyrima) is a selective and reversible inhibitor of MAO-A (RIMA).[1] As of 2007 it was in phase II clinical trials for the treatment of depression.[2] In 2013, work on the drug was terminated.[1]
References
- ^ Fielding R, Mielach F, Free J, Pande A (2007). Pharmacokinetics and oral bioavailability of CX157, a reversible selective MAO-A inhibitor, in primates (PDF). 2007 AAPS Annual Meeting & Exposition. Archived from the original (PDF) on 2011-05-26. Retrieved 2009-06-14.
- ^ Clinical trial number NCT00739908} for "A Study of CX157 (TriRima) for the Treatment of Depression (CX157-200)" at ClinicalTrials.gov
- v
- t
- e
Monoamine metabolism modulators
(dopamine, epinephrine,
norepinephrine)
PAHTooltip Phenylalanine hydroxylase |
|
---|---|
THTooltip Tyrosine hydroxylase |
|
DBHTooltip Dopamine beta-monooxygenase |
|
PNMTTooltip Phenylethanolamine N-methyltransferase |
|
COMTTooltip Catechol-O-methyl transferase |
|
(serotonin, melatonin)
TPHTooltip Tryptophan hydroxylase |
|
---|---|
AANATTooltip Serotonin N-acetyl transferase |
|
ASMTTooltip Acetylserotonin O-methyltransferase |
|
HDCTooltip Histidine decarboxylase |
|
---|---|
HNMTTooltip Histamine N-methyltransferase |
|
DAOTooltip Diamine oxidase |
|
See also: Receptor/signaling modulators • Adrenergics • Dopaminergics • Melatonergics • Serotonergics • Monoamine reuptake inhibitors • Monoamine releasing agents • Monoamine neurotoxins
This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it. |
- v
- t
- e