Mammalian protein found in Homo sapiens
CXCL13 |
---|
![](//upload.wikimedia.org/wikipedia/commons/thumb/8/8b/CXCL13.png/250px-CXCL13.png) |
Available structures |
---|
PDB | Ortholog search: PDBe RCSB |
---|
List of PDB id codes |
---|
4ZAI, 5CBA, 5CBE |
|
|
Identifiers |
---|
Aliases | CXCL13, ANGIE, ANGIE2, BCA-1, BCA1, BLC, BLR1L, SCYB13, C-X-C motif chemokine ligand 13 |
---|
External IDs | OMIM: 605149; MGI: 1888499; HomoloGene: 48431; GeneCards: CXCL13; OMA:CXCL13 - orthologs |
---|
Gene location (Human) |
---|
![Chromosome 4 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/0/04/Ideogram_human_chromosome_4.svg/300px-Ideogram_human_chromosome_4.svg.png) | Chr. | Chromosome 4 (human)[1] |
---|
| Band | 4q21.1 | Start | 77,511,753 bp[1] |
---|
End | 77,611,834 bp[1] |
---|
|
Gene location (Mouse) |
---|
![Chromosome 5 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ideogram_house_mouse_chromosome_5.svg/260px-Ideogram_house_mouse_chromosome_5.svg.png) | Chr. | Chromosome 5 (mouse)[2] |
---|
| Band | 5|5 E3 | Start | 96,104,810 bp[2] |
---|
End | 96,108,927 bp[2] |
---|
|
RNA expression pattern |
---|
Bgee | Human | Mouse (ortholog) |
---|
Top expressed in | - spleen
- lymph node
- appendix
- mucosa of ileum
- epithelium of nasopharynx
- rectum
- periodontal fiber
- tonsil
- superficial temporal artery
- decidua
|
| Top expressed in | - spleen
- mesenteric lymph nodes
- migratory enteric neural crest cell
- morula
- submandibular gland
- tunica adventitia of aorta
- subcutaneous adipose tissue
- Paneth cell
- white adipose tissue
- external carotid artery
|
| More reference expression data |
|
---|
BioGPS | |
---|
|
Gene ontology |
---|
Molecular function | - receptor ligand activity
- CCR10 chemokine receptor binding
- cytokine activity
- heparin binding
- CXCR3 chemokine receptor binding
- chemokine activity
- protein heterodimerization activity
- fibroblast growth factor binding
- CXCR5 chemokine receptor binding
| Cellular component | - extracellular region
- extracellular space
| Biological process | - chemokine-mediated signaling pathway
- positive regulation of cytosolic calcium ion concentration
- cell-cell signaling
- germinal center formation
- regulation of angiogenesis
- chemotaxis
- endothelial cell chemotaxis to fibroblast growth factor
- regulation of humoral immune response
- cell surface receptor signaling pathway
- response to lipopolysaccharide
- regulation of cell population proliferation
- defense response to bacterium
- negative regulation of endothelial cell chemotaxis to fibroblast growth factor
- positive regulation of T cell chemotaxis
- immune response
- inflammatory response
- chronic inflammatory response
- defense response
- antimicrobial humoral immune response mediated by antimicrobial peptide
- regulation of signaling receptor activity
- G protein-coupled receptor signaling pathway
- lymphocyte chemotaxis across high endothelial venule
- positive regulation of integrin activation
- positive regulation of cell-cell adhesion mediated by integrin
- B cell chemotaxis
- activation of GTPase activity
- neutrophil chemotaxis
- leukocyte chemotaxis
- cellular response to lipopolysaccharide
| Sources:Amigo / QuickGO |
|
Orthologs |
---|
Species | Human | Mouse |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (mRNA) | | |
---|
RefSeq (protein) | | |
---|
Location (UCSC) | Chr 4: 77.51 – 77.61 Mb | Chr 5: 96.1 – 96.11 Mb |
---|
PubMed search | [3] | [4] |
---|
|
Wikidata |
View/Edit Human | View/Edit Mouse |
|
Chemokine (C-X-C motif) ligand 13 (CXCL13), also known as B lymphocyte chemoattractant (BLC) or B cell-attracting chemokine 1 (BCA-1), is a protein ligand that in humans is encoded by the CXCL13 gene.[5][6]
Function
CXCL13 is a small chemokine belonging to the CXC chemokine family. As its other names suggest, this chemokine is selectively chemotactic for B cells belonging to both the B-1 and B-2 subsets, and elicits its effects by interacting with chemokine receptor CXCR5.[5][7] CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues[8] and is expressed highly in the liver, spleen, lymph nodes, and gut of humans.[5] The gene for CXCL13 is located on human chromosome 4 in a cluster of other CXC chemokines.[6]
In T lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T cell, particularly a subset of T cells called follicular B helper T cells (or TFH cells). Hence, expression of CXCL13 in T-cell lymphomas, such as angioimmunoblastic T-cell lymphoma, is thought to reflect a germinal center origin of the neoplastic T-cells.[9]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000156234 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023078 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c Legler DF, Loetscher M, Roos RS, Clark-Lewis I, Baggiolini M, Moser B (February 1998). "B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5". J. Exp. Med. 187 (4): 655–60. doi:10.1084/jem.187.4.655. PMC 2212150. PMID 9463416.
- ^ a b Gunn MD, Ngo VN, Ansel KM, Ekland EH, Cyster JG, Williams LT (February 1998). "A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1". Nature. 391 (6669): 799–803. Bibcode:1998Natur.391..799G. doi:10.1038/35876. PMID 9486651. S2CID 4373691.
- ^ Ansel KM, Harris RB, Cyster JG (January 2002). "CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity". Immunity. 16 (1): 67–76. doi:10.1016/S1074-7613(01)00257-6. PMID 11825566.
- ^ Ansel KM, Ngo VN, Hyman PL, Luther SA, Förster R, Sedgwick JD, Browning JL, Lipp M, Cyster JG (July 2000). "A chemokine-driven positive feedback loop organizes lymphoid follicles". Nature. 406 (6793): 309–14. doi:10.1038/35018581. PMID 10917533. S2CID 4369622.
- ^ de Leval L, Rickman DS, Thielen C, Reynies A, Huang YL, Delsol G, Lamant L, Leroy K, Brière J, Molina T, Berger F, Gisselbrecht C, Xerri L, Gaulard P (June 2007). "The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells". Blood. 109 (11): 4952–63. doi:10.1182/blood-2006-10-055145. PMID 17284527.
External links
- Human CXCL13 genome location and CXCL13 gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: O43927 (C-X-C motif chemokine 13) at the PDBe-KB.
By family | |
---|
By function/ cell | |
---|
![Stub icon](//upload.wikimedia.org/wikipedia/commons/thumb/6/61/DNA_stub.png/40px-DNA_stub.png) | This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it. |