Cephalotaxus alkaloids
Cephalotaxus alkaloids are natural products characterized by pentacyclic structure.
Occurrence
These alkaloids are commonly found in the plum yew species (Cephalotaxus), especially in the Japanese plum-yew.[1]
Representative
The most important representative is cephalotaxin. Other notable representatives include harringtonine and homoharringtonine.[1]
- (-)-Cephalotaxin
- (-)-Harringtonine
- (-)-Homoharringtonine
Properties
Harringtonine and homoharringtonine exhibit antitumor activity and act against murine leukemia cells. They serve as protein and DNA biosynthesis inhibitors and are used against acute myelocytoxic leukemia.[1]
References
- ^ a b c Entry on Cephalotaxus-Alkaloide. at: Römpp Online. Georg Thieme Verlag, retrieved {{{Datum}}}.Error in template * unknown parameter name (Template:RömppOnline): "Abruf"