DADLE
Synthetic opioid analgesic peptide
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Names | |
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IUPAC name (2R)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid | |
Other names • [D-Ala2, D-Leu5]-Enkephalin • L-Tyrosyl-D-alanylglycyl-L-phenylalanyl-D-Leucine • N-(N-(N-(N-L-tyrosyl-D-alanyl)glycyl)-L-phenylalanyl)-D-Leucine • Tyr-D-Ala-Gly-Phe-D-Leu-OH | |
Identifiers | |
CAS Number |
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3D model (JSmol) |
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ChemSpider |
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ECHA InfoCard | 100.059.337 ![]() |
PubChem CID |
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UNII |
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InChI
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Properties | |
Chemical formula | C29H39N5O7 |
Molar mass | 569.659 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ![]() ![]() ![]() Infobox references |
Chemical compound
DADLE ([D-Ala2, D-Leu5]-Enkephalin) is a synthetic opioid peptide with analgesic properties. Although it is often considered a selective δ-opioid receptor agonist, it also binds to the μ1 subtype of μ-opioid receptors.
Treatment with DADLE results in transient depression of mean arterial blood pressure and heart rate.[1][2]
Its peptide sequence is Tyr-D-Ala-Gly-Phe-D-Leu.
See also
- DAMGO
- DPDPE
References
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(MOR)
(DOR)
(KOR)
(NOP)
Agonists |
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Antagonists |
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- Enkephalinase inhibitors: Amastatin
- BL-2401
- Candoxatril
- D -Phenylalanine
- Dexecadotril (retorphan)
- Ecadotril (sinorphan)
- Kelatorphan
- Racecadotril (acetorphan)
- RB-101
- RB-120
- RB-3007
- Opiorphan
- Selank
- Semax
- Spinorphin
- Thiorphan
- Tynorphin
- Ubenimex (bestatin)
- Propeptides: β-Lipotropin (proendorphin)
- Prodynorphin
- Proenkephalin
- Pronociceptin
- Proopiomelanocortin (POMC)
- Others: Kyotorphin (met-enkephalin releaser/degradation stabilizer)
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