DNER

Protein-coding gene in the species Homo sapiens
DNER
Identifiers
AliasesDNER, UNQ26, bet, delta/notch like EGF repeat containing
External IDsOMIM: 607299; MGI: 2152889; HomoloGene: 26722; GeneCards: DNER; OMA:DNER - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for DNER
Genomic location for DNER
Band2q36.3Start229,357,629 bp[1]
End229,714,555 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for DNER
Genomic location for DNER
Band1|1 C5Start84,347,560 bp[2]
End84,673,942 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • lateral nuclear group of thalamus

  • cerebellar vermis

  • pars reticulata

  • Pars compacta

  • parotid gland

  • subthalamic nucleus

  • external globus pallidus

  • inferior ganglion of vagus nerve

  • superior vestibular nucleus

  • internal globus pallidus
Top expressed in
  • lobe of cerebellum

  • cerebellar vermis

  • ventromedial nucleus

  • barrel cortex

  • piriform cortex

  • habenula

  • mammillary body

  • ventral tegmental area

  • deep cerebellar nuclei

  • substantia nigra
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • clathrin binding
  • calcium ion binding
  • protein binding
  • transmembrane signaling receptor activity
  • Notch binding
Cellular component
  • integral component of membrane
  • neuronal cell body
  • plasma membrane
  • dendrite
  • early endosome
  • membrane
Biological process
  • Notch receptor processing
  • synapse assembly
  • central nervous system development
  • neuron migration
  • endocytosis
  • glial cell differentiation
  • skeletal muscle fiber development
  • Notch signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

92737

227325

Ensembl

ENSG00000187957

ENSMUSG00000036766

UniProt

Q8NFT8

Q8JZM4

RefSeq (mRNA)

NM_139072

NM_152915

RefSeq (protein)

NP_620711

NP_690879

Location (UCSC)Chr 2: 229.36 – 229.71 MbChr 1: 84.35 – 84.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Delta and Notch-like epidermal growth factor-related receptor is a protein that in humans is encoded by the DNER gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000187957 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036766 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Eiraku M, Hirata Y, Takeshima H, Hirano T, Kengaku M (Jul 2002). "Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons". J Biol Chem. 277 (28): 25400–7. doi:10.1074/jbc.M110793200. PMID 11950833.
  6. ^ Nishizumi H, Komiyama T, Miyabayashi T, Sakano S, Sakano H (May 2002). "BET, a novel neuronal transmembrane protein with multiple EGF-like motifs". NeuroReport. 13 (6): 909–15. doi:10.1097/00001756-200205070-00035. PMID 11997712. S2CID 8325151.
  7. ^ "Entrez Gene: DNER delta/notch-like EGF repeat containing".

Further reading

  • Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Ramachandran P, Boontheung P, Xie Y, et al. (2006). "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry". J. Proteome Res. 5 (6): 1493–503. doi:10.1021/pr050492k. PMID 16740002.


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