DUSP22 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/b/b6/PBB_Protein_DUSP22_image.jpg/250px-PBB_Protein_DUSP22_image.jpg) |
Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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1WRM, 4WOH |
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Identifiers |
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Aliases | DUSP22, JKAP, JSP-1, JSP1, LMW-DSP2, LMWDSP2, MKP-x, MKPX, VHX, dual specificity phosphatase 22 |
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External IDs | OMIM: 616778; MGI: 1915926; HomoloGene: 86039; GeneCards: DUSP22; OMA:DUSP22 - orthologs |
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Gene location (Human) |
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![Chromosome 6 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/0/03/Ideogram_human_chromosome_6.svg/300px-Ideogram_human_chromosome_6.svg.png) | Chr. | Chromosome 6 (human)[1] |
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| Band | 6p25.3 | Start | 291,630 bp[1] |
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End | 351,355 bp[1] |
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Gene location (Mouse) |
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![Chromosome 13 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/0/04/Ideogram_house_mouse_chromosome_13.svg/260px-Ideogram_house_mouse_chromosome_13.svg.png) | Chr. | Chromosome 13 (mouse)[2] |
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| Band | 13|13 A3.2 | Start | 30,843,982 bp[2] |
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End | 30,895,214 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - secondary oocyte
- gingival epithelium
- hair follicle
- visceral pleura
- monocyte
- gonad
- parietal pleura
- Brodmann area 23
- tibia
- endothelial cell
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| Top expressed in | - lip
- esophagus
- spermatid
- skin of external ear
- digastric muscle
- cumulus cell
- cornea
- skeletal muscle tissue
- thoracic diaphragm
- extraocular muscle
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/PBB_GE_DUSP22_218845_at_fs.png/250px-PBB_GE_DUSP22_218845_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - protein tyrosine phosphatase activity
- phosphatase activity
- phosphoprotein phosphatase activity
- hydrolase activity
- protein tyrosine/serine/threonine phosphatase activity
- non-membrane spanning protein tyrosine phosphatase activity
- protein tyrosine kinase binding
| Cellular component | - cytoplasm
- nucleus
- cytosol
- plasma membrane
- filamentous actin
- leading edge of lamellipodium
| Biological process | - multicellular organism development
- negative regulation of T cell mediated immunity
- protein dephosphorylation
- peptidyl-tyrosine dephosphorylation
- cell population proliferation
- negative regulation of T cell activation
- negative regulation of transcription by RNA polymerase II
- transforming growth factor beta receptor signaling pathway
- regulation of cell population proliferation
- positive regulation of JNK cascade
- negative regulation of T cell receptor signaling pathway
- dephosphorylation
- apoptotic process
- negative regulation of cell migration
- negative regulation of focal adhesion assembly
- cellular response to epidermal growth factor stimulus
- negative regulation of non-membrane spanning protein tyrosine kinase activity
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 6: 0.29 – 0.35 Mb | Chr 13: 30.84 – 30.9 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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