Denaverine

Chemical compound
  • Gr 1 (Germany)
Routes of
administrationintramuscular injection, suppositoriesATCvet code
  • QG02CX90 (WHO)
Legal statusLegal status
  • In general: ℞ (Prescription only)
Pharmacokinetic dataBioavailability8% (suppositories),
37% (oral solution)Metabolismmainly hepatic, at least 11 metabolitesElimination half-life34 hoursIdentifiers
  • 2-(Dimethylamino)ethyl (2-ethylbutoxy)diphenylacetate
CAS Number
  • 3579-62-2 checkY
    3321-06-0 (hydrochloride)
PubChem CID
  • 71130
ChemSpider
  • 64278 ☒N
UNII
  • O14NF38MTL
KEGG
  • D07787 checkY
ChEMBL
  • ChEMBL1614656 ☒N
CompTox Dashboard (EPA)
  • DTXSID10189315 Edit this at Wikidata
Chemical and physical dataFormulaC24H33NO3Molar mass383.532 g·mol−13D model (JSmol)
  • Interactive image
  • CCC(CC)COC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)OCCN(C)C
  • InChI=1S/C24H33NO3/c1-5-20(6-2)19-28-24(21-13-9-7-10-14-21,22-15-11-8-12-16-22)23(26)27-18-17-25(3)4/h7-16,20H,5-6,17-19H2,1-4H3 ☒N
  • Key:FPTOUQZVCUIPHY-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Denaverine is an antispasmodic drug. It was developed in Germany and patented in 1974. Denaverine hydrochloride is used in veterinary medicine under the trade name Sensiblex as a muscle relaxant for the myometrium of cows and dogs during parturition.[1] Under the trade name Spasmalgan, it has also been used in humans for the treatment of urogenital and gastrointestinal spasms.[2]

Mechanism of action

Denaverine, like papaverine, acts as a phosphodiesterase inhibitor. Additionally, it has anticholinergic effects.[3]

References

  1. ^ Committee for Veterinary Medicinal Products: Denavering Hydrochloride Summary Report
  2. ^ Dootz H, Kuhlmann A, Hoffmann K, eds. (2005). Rote Liste (in German) (2005 ed.). Aulendorf: Editio Cantor. 77 023. ISBN 3-87193-306-6.
  3. ^ Dinnendahl V, Fricke U, eds. (2010). Arzneistoff-Profile (in German). Vol. 4 (23 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. ISBN 978-3-7741-9846-3.


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