EIF4EBP3

Protein-coding gene in the species Homo sapiens
EIF4EBP3
Identifiers
AliasesEIF4EBP3, 4E-BP3, 4EBP3, eukaryotic translation initiation factor 4E binding protein 3
External IDsOMIM: 603483; MGI: 1270847; HomoloGene: 37841; GeneCards: EIF4EBP3; OMA:EIF4EBP3 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for EIF4EBP3
Genomic location for EIF4EBP3
Band5q31.3Start140,547,662 bp[1]
End140,549,576 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for EIF4EBP3
Genomic location for EIF4EBP3
Band18|18 B2Start36,797,113 bp[2]
End36,798,970 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • gastrocnemius muscle

  • olfactory zone of nasal mucosa

  • muscle of thigh

  • right adrenal cortex

  • body of stomach

  • left adrenal cortex

  • minor salivary glands

  • fundus

  • skin of leg
Top expressed in
  • ileum

  • renal cortex

  • proximal tubule

  • bone marrow

  • right kidney

  • liver

  • colon

  • jejunum

  • duodenum

  • human kidney
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • eukaryotic initiation factor 4E binding
  • translation repressor activity
Cellular component
  • cytoplasm
  • eukaryotic translation initiation factor 4F complex
  • membrane
Biological process
  • negative regulation of translation
  • regulation of translation
  • negative regulation of translational initiation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8637

108112

Ensembl

ENSG00000243056

ENSMUSG00000090264

UniProt

O60516

Q80VV3

RefSeq (mRNA)

NM_003732

NM_201256

RefSeq (protein)

NP_003723

NP_957708

Location (UCSC)Chr 5: 140.55 – 140.55 MbChr 18: 36.8 – 36.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Eukaryotic translation initiation factor 4E-binding protein 3 is a protein that in humans is encoded by the EIF4EBP3 gene.[5][6]

Function

This gene encodes a member of the EIF4EBP family which derives its name from proteins that bind to eukaryotic initiation factor 4E and that prevent its assembly into EIF4F. Co-transcription of this gene and the neighboring upstream gene (MASK) generates a transcript (MASK-BP3) which encodes a fusion protein composed of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments.[6]

Interactions

EIF4EBP3 has been shown to interact with EIF4E.[5][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000243056 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090264 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Poulin F, Gingras AC, Olsen H, Chevalier S, Sonenberg N (Jul 1998). "4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family". J. Biol. Chem. 273 (22): 14002–7. doi:10.1074/jbc.273.22.14002. PMID 9593750.
  6. ^ a b "Entrez Gene: EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3".
  7. ^ Kleijn M, Scheper GC, Wilson ML, Tee AR, Proud CG (Dec 2002). "Localisation and regulation of the eIF4E-binding protein 4E-BP3". FEBS Lett. 532 (3): 319–23. doi:10.1016/S0014-5793(02)03694-3. PMID 12482586. S2CID 24527449.

Further reading

  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Joshi B, Cameron A, Jagus R (2004). "Characterization of mammalian eIF4E-family members". Eur. J. Biochem. 271 (11): 2189–203. doi:10.1111/j.1432-1033.2004.04149.x. PMID 15153109.
  • Poulin F, Brueschke A, Sonenberg N (2003). "Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK". J. Biol. Chem. 278 (52): 52290–7. doi:10.1074/jbc.M310761200. PMID 14557257.
  • Ferguson G, Mothe-Satney I, Lawrence JC (2003). "Ser-64 and Ser-111 in PHAS-I are dispensable for insulin-stimulated dissociation from eIF4E". J. Biol. Chem. 278 (48): 47459–65. doi:10.1074/jbc.M307949200. PMID 14507920.
  • Kleijn M, Scheper GC, Wilson ML, Tee AR, Proud CG (2002). "Localisation and regulation of the eIF4E-binding protein 4E-BP3". FEBS Lett. 532 (3): 319–23. doi:10.1016/S0014-5793(02)03694-3. PMID 12482586. S2CID 24527449.