ENC1

Protein-coding gene in humans
ENC1
Identifiers
AliasesENC1, CCL28, ENC-1, KLHL35, KLHL37, NRPB, PIG10, TP53I10, ectodermal-neural cortex 1
External IDsOMIM: 605173; MGI: 109610; HomoloGene: 2694; GeneCards: ENC1; OMA:ENC1 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for ENC1
Genomic location for ENC1
Band5q13.3Start74,627,406 bp[1]
End74,641,424 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for ENC1
Genomic location for ENC1
Band13|13 D1Start97,241,105 bp[2]
End97,253,034 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Brodmann area 10

  • frontal pole

  • middle temporal gyrus

  • ganglionic eminence

  • orbitofrontal cortex

  • Brodmann area 46

  • superior frontal gyrus

  • Region I of hippocampus proper

  • ventricular zone

  • parietal lobe
Top expressed in
  • barrel cortex

  • medial ganglionic eminence

  • subiculum

  • anterior amygdaloid area

  • olfactory tubercle

  • prefrontal cortex

  • lateral septal nucleus

  • dorsal striatum

  • dentate gyrus of hippocampal formation granule cell

  • nucleus accumbens
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • actin binding
  • protein binding
Cellular component
  • cytoplasm
  • nuclear matrix
  • neuronal cell body
  • Cul3-RING ubiquitin ligase complex
  • nucleolus
  • cytoskeleton
  • nucleus
  • nucleoplasm
Biological process
  • multicellular organism development
  • negative regulation of translation
  • proteasomal ubiquitin-independent protein catabolic process
  • protein ubiquitination
  • nervous system development
  • positive regulation of neuron projection development
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8507

13803

Ensembl

ENSG00000171617

ENSMUSG00000041773

UniProt

O14682

O35709

RefSeq (mRNA)

NM_001256574
NM_001256575
NM_001256576
NM_003633

NM_007930

RefSeq (protein)

NP_001243503
NP_001243504
NP_001243505
NP_003624

NP_031956

Location (UCSC)Chr 5: 74.63 – 74.64 MbChr 13: 97.24 – 97.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ectoderm-neural cortex protein 1 is a protein that in humans is encoded by the ENC1 gene.[5][6][7]

Function

DNA damage and/or hyperproliferative signals activate wildtype p53 tumor suppressor protein (TP53; MIM 191170), inducing cell cycle arrest or apoptosis. Mutations that inactivate p53 occur in 50% of all tumors. Polyak et al. (1997) used serial analysis of gene expression (SAGE) to evaluate cellular mRNA levels in a colorectal cancer cell line transfected with p53. Of 7,202 transcripts identified, only 14 were expressed at levels more than 10-fold higher in p53-expressing cells than in control cells. Polyak et al. (1997) termed these genes 'p53-induced genes,' or PIGs, several of which were predicted to encode redox-controlling proteins. They noted that reactive oxygen species (ROS) are potent inducers of apoptosis. Flow cytometric analysis showed that p53 expression induces ROS production, which increases as apoptosis progresses under some conditions. The authors stated that the PIG10 gene, also called ENC1, encodes an actin-binding protein.[supplied by OMIM][7]

Interactions

ENC1 has been shown to interact with Retinoblastoma protein.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171617 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041773 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B (Sep 1997). "A model for p53-induced apoptosis". Nature. 389 (6648): 300–5. Bibcode:1997Natur.389..300P. doi:10.1038/38525. PMID 9305847. S2CID 4429638.
  6. ^ a b Kim TA, Lim J, Ota S, Raja S, Rogers R, Rivnay B, Avraham H, Avraham S (May 1998). "NRP/B, a novel nuclear matrix protein, associates with p110(RB) and is involved in neuronal differentiation". The Journal of Cell Biology. 141 (3): 553–66. doi:10.1083/jcb.141.3.553. PMC 2132755. PMID 9566959.
  7. ^ a b "Entrez Gene: ENC1 ectodermal-neural cortex (with BTB-like domain)".

Further reading

  • Hernandez MC, Andres-Barquin PJ, Holt I, Israel MA (Aug 1998). "Cloning of human ENC-1 and evaluation of its expression and regulation in nervous system tumors". Experimental Cell Research. 242 (2): 470–7. doi:10.1006/excr.1998.4109. PMID 9683534.
  • Hernandez MC, Andres-Barquin PJ, Kuo WL, Israel MA (2000). "Assignment of the ectodermal-neural cortex 1 gene (ENC1) to human chromosome band 5q13 by in situ hybridization". Cytogenetics and Cell Genetics. 87 (1–2): 89–90. doi:10.1159/000015398. PMID 10640818. S2CID 40487726.
  • Zhao L, Gregoire F, Sul HS (Jun 2000). "Transient induction of ENC-1, a Kelch-related actin-binding protein, is required for adipocyte differentiation". The Journal of Biological Chemistry. 275 (22): 16845–50. doi:10.1074/jbc.275.22.16845. PMID 10828068.
  • Kim TA, Ota S, Jiang S, Pasztor LM, White RA, Avraham S (Sep 2000). "Genomic organization, chromosomal localization and regulation of expression of the neuronal nuclear matrix protein NRP/B in human brain tumors". Gene. 255 (1): 105–16. doi:10.1016/S0378-1119(00)00297-3. PMID 10974570.
  • Fujita M, Furukawa Y, Tsunoda T, Tanaka T, Ogawa M, Nakamura Y (Nov 2001). "Up-regulation of the ectodermal-neural cortex 1 (ENC1) gene, a downstream target of the beta-catenin/T-cell factor complex, in colorectal carcinomas". Cancer Research. 61 (21): 7722–6. PMID 11691783.
  • Hammarsund M, Lerner M, Zhu C, Merup M, Jansson M, Gahrton G, Kluin-Nelemans H, Einhorn S, Grandér D, Sangfelt O, Corcoran M (Dec 2004). "Disruption of a novel ectodermal neural cortex 1 antisense gene, ENC-1AS and identification of ENC-1 overexpression in hairy cell leukemia". Human Molecular Genetics. 13 (23): 2925–36. doi:10.1093/hmg/ddh315. PMID 15459180.
  • Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (Mar 2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Seng S, Avraham HK, Jiang S, Yang S, Sekine M, Kimelman N, Li H, Avraham S (Sep 2007). "The nuclear matrix protein, NRP/B, enhances Nrf2-mediated oxidative stress responses in breast cancer cells". Cancer Research. 67 (18): 8596–604. doi:10.1158/0008-5472.CAN-06-3785. PMID 17875699.