EDN1 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/7/75/PDB_1edn_EBI.jpg/250px-PDB_1edn_EBI.jpg) |
Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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1EDN, 1EDP, 1T7H, 1V6R, 6DK5, 5GLH |
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Identifiers |
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Aliases | EDN1, ARCND3, ET1, HDLCQ7, QME, endothelin 1, PPET1 |
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External IDs | MGI: 95283; HomoloGene: 1476; GeneCards: EDN1; OMA:EDN1 - orthologs |
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Gene location (Human) |
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![Chromosome 6 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/0/03/Ideogram_human_chromosome_6.svg/300px-Ideogram_human_chromosome_6.svg.png) | Chr. | Chromosome 6 (human)[1] |
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| Band | 6p24.1 | Start | 12,290,361 bp[1] |
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End | 12,297,194 bp[1] |
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Gene location (Mouse) |
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![Chromosome 13 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/0/04/Ideogram_house_mouse_chromosome_13.svg/260px-Ideogram_house_mouse_chromosome_13.svg.png) | Chr. | Chromosome 13 (mouse)[2] |
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| Band | 13 A4|13 20.82 cM | Start | 42,454,952 bp[2] |
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End | 42,461,466 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - lower lobe of lung
- buccal mucosa cell
- right lung
- subcutaneous adipose tissue
- upper lobe of left lung
- skin of hip
- human penis
- islet of Langerhans
- tibial nerve
- rectum
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| Top expressed in | - pharynx
- vasculature of trunk
- Aortic arches
- right lung lobe
- dorsal aorta
- endothelial cell of lymphatic vessel
- left colon
- vascular endothelium
- left lung lobe
- external carotid artery
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/1/1a/PBB_GE_EDN1_218995_s_at_fs.png/250px-PBB_GE_EDN1_218995_s_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - hormone activity
- signaling receptor binding
- cytokine activity
- endothelin B receptor binding
- protein binding
- endothelin A receptor binding
| Cellular component | - cytoplasm
- Weibel-Palade body
- basal part of cell
- extracellular region
- rough endoplasmic reticulum lumen
- extracellular space
- transport vesicle
| Biological process | | Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | |
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NP_001161791 NP_001946 NP_001161791 NP_001946 |
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Location (UCSC) | Chr 6: 12.29 – 12.3 Mb | Chr 13: 42.45 – 42.46 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Endothelin 1 (ET-1), also known as preproendothelin-1 (PPET1), is a potent vasoconstrictor peptide produced by vascular endothelial cells,[5] as well as by cells in the heart (affecting contractility) and kidney (affecting sodium handling).[6] The protein encoded by this gene – EDN1 – is proteolytically processed to release endothelin 1. Endothelin 1 is one of three isoforms of human endothelin.
Sources
Preproendothelin is precursor of the peptide ET-1. Endothelial cells convert preproendothelin to proendothelin and subsequently to mature endothelin, which the cells release.[5][7]
Clinical significance
Patients with salt-sensitive hypertension have higher plasma ET-1.[6] Endothelin-1 receptor antagonists (Bosentan) are used in the treatment of pulmonary hypertension.[5] Use of these antagonists prevents pulmonary arterial constriction and thus inhibits pulmonary hypertension.[5]
As of 2020, the role of endothelin-1 in affecting lipid metabolism and insulin resistance in obesity mechanisms was under clinical research.[8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000078401 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021367 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c d Davenport AP, Hyndman KA, Dhaun N, Southan C, Kohan DE, Pollock JS, et al. (April 2016). "Endothelin". Pharmacological Reviews. 68 (2): 357–418. doi:10.1124/pr.115.011833. PMC 4815360. PMID 26956245.
- ^ a b Jankowich M, Choudhary G (2020). "Endothelin-1 levels and cardiovascular events". Trends in Cardiovascular Medicine. 30 (1): 1–8. doi:10.1016/j.tcm.2019.01.007. PMID 30765295.
- ^ Boulpaep EL, Boron WF (2009). Medical physiology: a cellular and molecular approach. Saunders/Elsevier. ISBN 978-1-4160-3115-4.
- ^ Jenkins HN, Rivera-Gonzalez O, Gibert Y, Speed JS (December 2020). "Endothelin-1 in the pathophysiology of obesity and insulin resistance". Obesity Reviews. 21 (12): e13086. doi:10.1111/obr.13086. PMC 7669671. PMID 32627269.
External links
- Overview of all the structural information available in the PDB for UniProt: P05305 (Endothelin-1) at the PDBe-KB.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.