Estriol dihexanoate
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Other names | Oestriol dihexanoate; Estriol 3,17β-dihexanoate; 16α-Hydroxyestra-1,3,5(10)-triene-3,17β-diyl dihexanoate |
Routes of administration | Intramuscular injection |
Drug class | Estrogen; Estrogen ester |
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Formula | C30H44O5 |
Molar mass | 484.677 g·mol−1 |
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Estriol dihexanoate, or estriol 3,17β-dihexanoate, is a synthetic estrogen and estrogen ester – specifically, the C3 and C17β dihexanoate ester of estriol – which was first described in 1963 and was never marketed.[1][2][3] Following a single intramuscular injection of 8.90 mg estriol dihexanoate (equivalent to 5.0 mg estriol) in an oil solution, peak levels of estriol occurred after 2.1 to 3.4 days, an elimination half-life of 187 to 221 hours was observed, and estriol levels remained elevated for up to 20 to 50 days.[1][3] For comparison, the durations of estriol and estriol dipropionate were far shorter.[1][3]
See also
References
- ^ a b c Kuhnz W, Blode H, Zimmermann H (6 December 2012). "Pharmacokinetics of exogenous natural and synthetic estrogens and antiestrogens". In Oettel M, Schillinger E (eds.). Estrogens and Antiestrogens II: Pharmacology and Clinical Application of Estrogens and Antiestrogen. Springer Science & Business Media. pp. 273–. ISBN 978-3-642-60107-1.
- ^ Tsuneda K, Yamada J, Yasuda K, Mori H (April 1963). "Preparation of some estriol esters". Chemical & Pharmaceutical Bulletin. 11 (4): 510–514. doi:10.1248/cpb.11.510. PMID 13994597.
- ^ a b c Heithecker R, Aedo AR, Landgren BM, Cekan SZ (1991). "Plasma estriol levels after intramuscular injection of estriol and two of its esters". Hormone Research. 35 (6): 234–238. doi:10.1159/000181911. PMID 1819548.
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- See also
- Receptor/signaling modulators
- Estrogens and antiestrogens
- Androgen receptor modulators
- Progesterone receptor modulators
- List of estrogens
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