Exodeoxyribonuclease III
Exodeoxyribonuclease III | |||||||||
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Identifiers | |||||||||
EC no. | 3.1.11.2 | ||||||||
CAS no. | 9037-44-9 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Exodeoxyribonuclease III (EC 3.1.11.2, Escherichia coli exonuclease III, E. coli exonuclease III, endoribonuclease III) is an enzyme[1][2][3] that catalyses the following reaction
- Exonucleolytic cleavage in the 3′- to 5′-direction to yield nucleoside 5′-phosphates
This enzyme has a preference for double-stranded DNA.
References
- ^ Lindahl T, Gally JA, Edelman GM (September 1969). "Properties of deoxyribonuclease 3 from mammalian tissues". The Journal of Biological Chemistry. 244 (18): 5014–9. doi:10.1016/S0021-9258(18)94303-6. PMID 5824576.
- ^ Richardson CC, Kornberg A (January 1964). "A deoxyribonucleic acid phosphatase-exonuclease from Escherichia coli. I. Purification of the enzyme and characterization of the phosphatase activity". The Journal of Biological Chemistry. 239: 242–50. doi:10.1016/S0021-9258(18)51774-9. PMID 14114850.
- ^ Richardson CC, Lehman IR, Kornberg A (January 1964). "A deoxyribonucleic acid phosphatase-exonuclease from Escherichia coli. II. Characterization of the exonuclease activity". The Journal of Biological Chemistry. 239: 251–8. doi:10.1016/S0021-9258(18)51775-0. PMID 14114851.
External links
- Exodeoxyribonuclease+III at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- v
- t
- e
Hydrolase: esterases (EC 3.1)
ester hydrolases
- Alkaline phosphatase
- Acid phosphatase (Prostatic)/Tartrate-resistant acid phosphatase/Purple acid phosphatases
- Nucleotidase
- Glucose 6-phosphatase
- Fructose 1,6-bisphosphatase
- Protein phosphatase
- OCRL
- Pyruvate dehydrogenase phosphatase
- Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase
- PTEN
- Phytase
- Inositol-phosphate phosphatase
- Protein phosphatase: Protein tyrosine phosphatase
- Protein serine/threonine phosphatase
- Dual-specificity phosphatase
Phosphodiesterase
deoxyribonuclease
and ribonuclease)
3.1.11-16: Exonuclease |
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3.1.21-31: Endonuclease |
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