FASTK

Protein-coding gene in the species Homo sapiens

FASTK

Identifiers

Aliases

FASTK, Fastk, 0610011K02Rik, 610011K02Rik, FAST, Fas activated serine/threonine kinase

External IDs

OMIM: 606965; MGI: 1913837; HomoloGene: 4884; GeneCards: FASTK; OMA:FASTK - orthologs

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	7q36.1	Start	151,076,624 bp^[1]
Band	7q36.1	End	151,080,866 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5\|5 A3	Start	24,643,438 bp^[2]
Band	5\|5 A3	End	24,650,285 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

apex of heart

muscle of thigh

right hemisphere of cerebellum

mucosa of transverse colon

anterior pituitary

gastrocnemius muscle

right lobe of thyroid gland

right uterine tube

right lobe of liver

left lobe of thyroid gland

Top expressed in

muscle of thigh

extensor digitorum longus muscle

superior frontal gyrus

myocardium of ventricle

cardiac muscles

interventricular septum

medial head of gastrocnemius muscle

primary visual cortex

thoracic diaphragm

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	kinase activity transferase activity nucleotide binding protein serine/threonine kinase activity protein kinase activity protein binding Fas-activated serine/threonine kinase activity ATP binding RNA binding
Cellular component	mitochondrion mitochondrial matrix
Biological process	apoptotic signaling pathway protein phosphorylation regulation of RNA splicing phosphorylation apoptotic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10922


66587

Ensembl


ENSG00000164896


ENSMUSG00000028959

UniProt


Q14296


Q9JIX9

RefSeq (mRNA)


NM_001258461 NM_006712 NM_033015


NM_023229

RefSeq (protein)


NP_001245390 NP_006703 NP_148936


n/a

Location (UCSC)

Chr 7: 151.08 – 151.08 Mb

Chr 5: 24.64 – 24.65 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Fas-activated serine/threonine kinase is an enzyme that in humans is encoded by the FASTK gene.^[5]^[6]^[7]

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates the apoptosis-promoting nuclear RNA-binding protein TIA1. The encoded protein is a strong inducer of lymphocyte apoptosis.

Two transcript variants encoding different isoforms have been found for this gene. The longer one is located in the cell nucleus and cytoplasm, and the shorter one is 34 amino acids at the N-terminus, which is transported to the mitochondrion.^[8]

The mitochondrial FASTK isoform localizes in the mitochondrial granules, where it interacts with the GRSF1 protein and binds to mt-mRNA ND6, the template of the only protein encoded on the light strand of the mitochondrial genome. In the case of FASTK deletion, it was observed loss of ND6 mt-mRNA and a 50-60% decrease in the activity of complex I of the respiratory chain. However, overexpression of this protein resulted in the stabilization of ND6 mt-mRNA ^[8]^[9]

Other variants exist, but their full-length natures have not yet been determined.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164896 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028959 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tian Q, Taupin J, Elledge S, Robertson M, Anderson P (September 1995). "Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis". The Journal of Experimental Medicine. 182 (3): 865–874. doi:10.1084/jem.182.3.865. PMC 2192163. PMID 7544399.
^ Li W, Simarro M, Kedersha N, Anderson P (December 2004). "FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression". Molecular and Cellular Biology. 24 (24): 10718–10732. doi:10.1128/MCB.24.24.10718-10732.2004. PMC 533970. PMID 15572676.
^ ^a ^b "Entrez Gene: FASTK Fas-activated serine/threonine kinase".
^ ^a ^b Jourdain AA, Popow J, de la Fuente MA, Martinou JC, Anderson P, Simarro M (November 2017). "The FASTK family of proteins: emerging regulators of mitochondrial RNA biology". Nucleic Acids Research. 45 (19): 10941–10947. doi:10.1093/nar/gkx772. PMC 5737537. PMID 29036396.
^ Jourdain AA, Koppen M, Rodley CD, Maundrell K, Gueguen N, Reynier P, et al. (February 2015). "A mitochondria-specific isoform of FASTK is present in mitochondrial RNA granules and regulates gene expression and function". Cell Reports. 10 (7): 1110–1121. doi:10.1016/j.celrep.2015.01.063. hdl:10261/157664. PMID 25704814.

Auffray C, Behar G, Bois F, Bouchier C, Da Silva C, Devignes MD, et al. (February 1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences. Série III, Sciences de la Vie. 318 (2): 263–272. PMID 7757816.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Li W, Kedersha N, Chen S, Gilks N, Lee G, Anderson P (May 2004). "FAST is a BCL-X(L)-associated mitochondrial protein". Biochemical and Biophysical Research Communications. 318 (1): 95–102. doi:10.1016/j.bbrc.2004.03.188. PMID 15110758.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, et al. (December 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome. 16 (12): 942–954. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
Izquierdo JM, Valcárcel J (January 2007). "Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing". The Journal of Biological Chemistry. 282 (3): 1539–1543. doi:10.1074/jbc.C600198200. PMID 17135269.
Simarro M, Mauger D, Rhee K, Pujana MA, Kedersha NL, Yamasaki S, et al. (July 2007). "Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing". Proceedings of the National Academy of Sciences of the United States of America. 104 (27): 11370–11375. Bibcode:2007PNAS..10411370S. doi:10.1073/pnas.0704964104. PMC 2040905. PMID 17592127.

Kinases: Serine/threonine-specific protein kinases (EC 2.7.11-12)

Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)

Non-specific serine/threonine protein kinases (EC 2.7.11.1)	LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1
Pyruvate dehydrogenase kinase (EC 2.7.11.2)	PDK1 PDK2 PDK3 PDK4
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)	AMP-activated protein kinase α PRKAA1 PRKAA2 β PRKAB1 PRKAB2 γ PRKAG1 PRKAG2 PRKAG3
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)	BCKDK BCKDHA BCKDHB
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)	IDH2 IDH3A IDH3B IDH3G
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)	STK4
Myosin-heavy-chain kinase (EC 2.7.11.7)	Aurora kinase Aurora A kinase Aurora B kinase Aurora C kinase
Fas-activated serine/threonine kinase (EC 2.7.11.8)	FASTK STK10
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)	-
IκB kinase (EC 2.7.11.10)	CHUK IKK2 TBK1 IKBKE IKBKG IKBKAP
cAMP-dependent protein kinase (EC 2.7.11.11)	Protein kinase A PRKACG PRKACB PRKACA PRKY
cGMP-dependent protein kinase (EC 2.7.11.12)	Protein kinase G PRKG1
Protein kinase C (EC 2.7.11.13)	Protein kinase C Protein kinase Cζ PKC alpha PRKCB1 PRKCD PRKCE PRKCH PRKCG PRKCI PRKCQ Protein kinase N1 PKN2 PKN3
Rhodopsin kinase (EC 2.7.11.14)	Rhodopsin kinase
Beta adrenergic receptor kinase (EC 2.7.11.15)	Beta adrenergic receptor kinase Beta adrenergic receptor kinase-2
G-protein coupled receptor kinases (EC 2.7.11.16)	GRK4 GRK5 GRK6
Ca2+/calmodulin-dependent (EC 2.7.11.17)	BRSK2 CAMK1 CAMK1A CAMK1B CAMK1D CAMK1G CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 MLCK CASK CHEK1 CHEK2 DAPK1 DAPK2 DAPK3 STK11 MAPKAPK2 MAPKAPK3 MAPKAPK5 MARK1 MARK2 MARK3 MARK4 MELK MKNK1 MKNK2 NUAK1 NUAK2 OBSCN PASK PHKG1 PHKG2 PIM1 PIM2 PKD1 PRKD2 PRKD3 PSKH1 SNF1LK2 KIAA0999 STK40 SNF1LK SNRK SPEG TSSK2 Kalirin TRIB1 TRIB2 TRIB3 TRIO Titin DCLK1
Myosin light-chain kinase (EC 2.7.11.18)	MYLK MYLK2 MYLK3 MYLK4
Phosphorylase kinase (EC 2.7.11.19)	PHKA1 PHKA2 PHKB PHKG1 PHKG2
Elongation factor 2 kinase (EC 2.7.11.20)	EEF2K STK19
Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4

Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)

Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4
Cyclin-dependent kinase (EC 2.7.11.22)	CDK1 CDK2 CDKL2 CDK3 CDK4 CDK5 CDKL5 CDK6 CDK7 CDK8 CDK9 CDK10 CDK12 CDC2L5 PCTK1 PCTK2 PCTK3 PFTK1 CDC2L1
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)	RPS6KA5 RPS6KA4 P70S6 kinase P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1
Mitogen-activated protein kinase (EC 2.7.11.24)	Extracellular signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14
MAP3K (EC 2.7.11.25)	MAP kinase kinase kinases MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAP3K8 RAFs ARAF BRAF KSR1 KSR2 MLKs MAP3K12 MAP3K13 MAP3K9 MAP3K10 MAP3K11 MAP3K7 ZAK CDC7 MAP3K14
Tau-protein kinase (EC 2.7.11.26)	TPK1 TTK GSK-3
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)	-
Tropomyosin kinase (EC 2.7.11.28)	-
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)	-
Receptor protein serine/threonine kinase (EC 2.7.11.30)	Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

Dual-specificity kinases (EC 2.7.12)

MAP2K	MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)