FCHO2

Protein-coding gene in the species Homo sapiens
FCHO2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2V0O

Identifiers
AliasesFCHO2, FCH domain only 2, FCH and mu domain containing endocytic adaptor 2
External IDsOMIM: 613438; MGI: 3505790; HomoloGene: 9030; GeneCards: FCHO2; OMA:FCHO2 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for FCHO2
Genomic location for FCHO2
Band5q13.2Start72,956,041 bp[1]
End73,090,522 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for FCHO2
Genomic location for FCHO2
Band13|13 D1Start98,859,911 bp[2]
End98,951,957 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of ileum

  • Achilles tendon

  • tibialis anterior muscle

  • skin of hip

  • jejunal mucosa

  • skin of thigh

  • lower lobe of lung

  • oral cavity

  • mucosa of pharynx

  • visceral pleura
Top expressed in
  • interventricular septum

  • granulocyte

  • superior cervical ganglion

  • epithelium of small intestine

  • zygote

  • tail of embryo

  • hand

  • carotid body

  • suprachiasmatic nucleus

  • otolith organ
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • phosphatidylinositol-4,5-bisphosphate binding
  • phosphatidylserine binding
  • protein binding
  • phosphatidylinositol binding
  • identical protein binding
  • phospholipid binding
  • microtubule binding
  • cytoskeletal protein binding
  • tubulin binding
Cellular component
  • plasma membrane
  • clathrin-coated pit
  • membrane
  • clathrin-coated vesicle
  • cytosol
  • presynaptic endocytic zone membrane
  • cytoplasm
  • cytoskeleton
  • AP-2 adaptor complex
Biological process
  • membrane invagination
  • protein localization to plasma membrane
  • endocytosis
  • clathrin coat assembly
  • synaptic vesicle endocytosis
  • membrane organization
  • clathrin-dependent endocytosis
  • plasma membrane tubulation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

115548

218503

Ensembl

ENSG00000157107

ENSMUSG00000041685

UniProt

Q0JRZ9

Q3UQN2

RefSeq (mRNA)

NM_138782
NM_001146032

NM_172591

RefSeq (protein)

NP_001139504
NP_620137

NP_766179

Location (UCSC)Chr 5: 72.96 – 73.09 MbChr 13: 98.86 – 98.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FCH domain only protein 2 is a protein that in humans is encoded by the FCHO2 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000157107 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041685 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Katoh M, Katoh M (Aug 2004). "Identification and characterization of human FCHO2 and mouse Fcho2 genes in silico". International Journal of Molecular Medicine. 14 (2): 327–31. doi:10.3892/ijmm.14.2.327. PMID 15254787.
  6. ^ "Entrez Gene: FCHO2 FCH domain only 2".

Further reading

  • Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Henne WM, Kent HM, Ford MG, Hegde BG, Daumke O, Butler PJ, Mittal R, Langen R, Evans PR, McMahon HT (Jul 2007). "Structure and analysis of FCHo2 F-BAR domain: a dimerizing and membrane recruitment module that effects membrane curvature". Structure. 15 (7): 839–52. doi:10.1016/j.str.2007.05.002. PMID 17540576.


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