FGD2

Protein-coding gene in the species Homo sapiens
FGD2
Identifiers
AliasesFGD2, ZFYVE4, FYVE, RhoGEF and PH domain containing 2
External IDsOMIM: 605091; MGI: 1347084; HomoloGene: 8438; GeneCards: FGD2; OMA:FGD2 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for FGD2
Genomic location for FGD2
Band6p21.2Start37,005,646 bp[1]
End37,029,069 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for FGD2
Genomic location for FGD2
Band17 15.26 cM|17 A3.3Start29,360,914 bp[2]
End29,379,661 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • spleen

  • granulocyte

  • epithelium of nasopharynx

  • internal globus pallidus

  • lymph node

  • buccal mucosa cell

  • blood

  • trabecular bone

  • cardia
Top expressed in
  • otic vesicle

  • saccule

  • spleen

  • granulocyte

  • blood

  • otic placode

  • islet of Langerhans

  • stroma of bone marrow

  • mesenteric lymph nodes

  • epiblast
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • phosphatidylinositol phosphate binding
  • metal ion binding
  • small GTPase binding
  • protein binding
  • guanyl-nucleotide exchange factor activity
Cellular component
  • cytoplasm
  • cytosol
  • endosome
  • Golgi apparatus
  • cell projection
  • early endosome membrane
  • membrane
  • ruffle
  • plasma membrane
  • ruffle membrane
  • early endosome
  • cytoskeleton
  • nucleus
  • lamellipodium
Biological process
  • positive regulation of JUN kinase activity
  • regulation of GTPase activity
  • filopodium assembly
  • cytoskeleton organization
  • regulation of cell shape
  • positive regulation of apoptotic process
  • regulation of Rho protein signal transduction
  • regulation of small GTPase mediated signal transduction
  • actin cytoskeleton organization
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

221472

26382

Ensembl

ENSG00000146192

ENSMUSG00000024013

UniProt

Q7Z6J4

Q8BY35

RefSeq (mRNA)

NM_173558

NM_001159538
NM_013710

RefSeq (protein)

NP_775829

NP_001153010
NP_038738

Location (UCSC)Chr 6: 37.01 – 37.03 MbChr 17: 29.36 – 29.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FYVE, RhoGEF and PH domain-containing protein 2 (FGD2), also known as zinc finger FYVE domain-containing protein 4 (ZFYVE4), is a protein that in humans is encoded by the FGD2 gene.[5]

It is a member of the FYVE, RhoGEF and PH domain containing family.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146192 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024013 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: FYVE".

Further reading

  • Salehi AH, Xanthoudakis S, Barker PA (2002). "NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway". J. Biol. Chem. 277 (50): 48043–50. doi:10.1074/jbc.M205324200. PMID 12376548.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Hattori A, Okumura K, Nagase T, et al. (2000). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.
  • Pasteris NG, Gorski JL (1999). "Isolation, characterization, and mapping of the mouse and human Fgd2 genes, faciogenital dysplasia (FGD1; Aarskog syndrome) gene homologues". Genomics. 60 (1): 57–66. doi:10.1006/geno.1999.5903. PMID 10458911.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Harrington AW, Kim JY, Yoon SO (2002). "Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis". J. Neurosci. 22 (1): 156–66. doi:10.1523/JNEUROSCI.22-01-00156.2002. PMC 6757583. PMID 11756498.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Rabizadeh S, Bredesen DE (2003). "Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR)". Cytokine Growth Factor Rev. 14 (3–4): 225–39. doi:10.1016/S1359-6101(03)00018-2. PMID 12787561.
  • Huber C, Mårtensson A, Bokoch GM, et al. (2008). "FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles". J. Biol. Chem. 283 (49): 34002–12. doi:10.1074/jbc.M803957200. PMC 2590680. PMID 18838382.
  • Delague V, Jacquier A, Hamadouche T, et al. (2007). "Mutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4H". Am. J. Hum. Genet. 81 (1): 1–16. doi:10.1086/518428. PMC 1950914. PMID 17564959.


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