FGD3

Protein-coding gene in the species Homo sapiens
FGD3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2COC

Identifiers
AliasesFGD3, ZFYVE5, FYVE, RhoGEF and PH domain containing 3
External IDsOMIM: 617554; MGI: 1353657; HomoloGene: 22925; GeneCards: FGD3; OMA:FGD3 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for FGD3
Genomic location for FGD3
Band9q22.31Start92,947,523 bp[1]
End93,036,236 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for FGD3
Genomic location for FGD3
Band13 A5|13 25.18 cMStart49,415,030 bp[2]
End49,473,787 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • blood

  • thymus

  • monocyte

  • spleen

  • bone marrow cells

  • trabecular bone

  • pancreatic ductal cell

  • lymph node

  • appendix
Top expressed in
  • granulocyte

  • gastrula

  • yolk sac

  • embryo

  • thymus

  • visual cortex

  • dentate gyrus of hippocampal formation granule cell

  • cerebellar cortex

  • primary visual cortex

  • submandibular gland
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • metal ion binding
  • small GTPase binding
  • guanyl-nucleotide exchange factor activity
Cellular component
  • cytoplasm
  • cytosol
  • Golgi apparatus
  • ruffle
  • cytoskeleton
  • lamellipodium
Biological process
  • regulation of GTPase activity
  • filopodium assembly
  • cytoskeleton organization
  • regulation of cell shape
  • positive regulation of apoptotic process
  • regulation of Rho protein signal transduction
  • regulation of small GTPase mediated signal transduction
  • actin cytoskeleton organization
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

89846

30938

Ensembl

ENSG00000127084

ENSMUSG00000037946

UniProt

Q5JSP0

O88842

RefSeq (mRNA)

NM_001083536
NM_001286993
NM_033086
NM_001369951
NM_001369952

NM_015759

RefSeq (protein)
NP_001077005
NP_001273922
NP_149077
NP_001356880
NP_001356881

NP_001077005.1
NP_149077.2

n/a

Location (UCSC)Chr 9: 92.95 – 93.04 MbChr 13: 49.42 – 49.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FYVE, RhoGEF and PH domain-containing protein 3 is a protein that in humans is encoded by the FGD3 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000127084 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037946 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hattori A, Okumura K, Nagase T, Kikuno R, Hirosawa M, Ohara O (Feb 2001). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.
  6. ^ "Entrez Gene: FGD3 FYVE, RhoGEF and PH domain containing 3".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Pasteris NG, Nagata K, Hall A, Gorski JL (2000). "Isolation, characterization, and mapping of the mouse Fgd3 gene, a new Faciogenital Dysplasia (FGD1; Aarskog Syndrome) gene homologue". Gene. 242 (1–2): 237–47. doi:10.1016/S0378-1119(99)00518-1. PMID 10721717.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Delague V, Jacquier A, Hamadouche T, et al. (2007). "Mutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4H". Am. J. Hum. Genet. 81 (1): 1–16. doi:10.1086/518428. PMC 1950914. PMID 17564959.

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human FYVE, RhoGEF and PH domain-containing protein 3 (FGD3)
  • v
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  • e
  • 2coc: Solution structure of the C-terminal PH domain of FYVE, RhoGEF and PH domain containing protein 3 (FGD3) from human
    2coc: Solution structure of the C-terminal PH domain of FYVE, RhoGEF and PH domain containing protein 3 (FGD3) from human


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