Ferric derisomaltose

Medication

US DailyMed: Ferric derisomaltose

Routes of
administrationIntravenousATC code

None

Legal statusLegal status

AU: S4 (Prescription only)^[1]^[2]
CA: ℞-only^[3]
US: ℞-only^[4]

Identifiers

IUPAC name

iron(3+);(2S,3R,4R,5R)-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxyhexane-1,2,3,4,5-pentol

CAS Number

1345510-43-1

PubChem CID

86278348

DrugBank

DB15617

UNII

AHU547PI9H

KEGG

D11808

Chemical and physical dataFormulaC₁₈H₃₄FeO₁₆⁺³Molar mass562.299 g·mol⁻¹3D model (JSmol)

Interactive image

SMILES

C(C1C(C(C(C(O1)OCC2C(C(C(C(O2)OCC(C(C(C(CO)O)O)O)O)O)O)O)O)O)O)O.[Fe+3]

InChI

InChI=1S/C18H34O16.Fe/c19-1-5(21)9(23)10(24)6(22)3-31-17-16(30)14(28)12(26)8(34-17)4-32-18-15(29)13(27)11(25)7(2-20)33-18;/h5-30H,1-4H2;/q;+3/t5-,6+,7+,8+,9+,10+,11+,12+,13-,14-,15+,16+,17-,18-;/m0./s1
Key:JTQTXQSGPZRXJF-DOJSGGEQSA-N

Ferric derisomaltose, sold under the brand name Monoferric among others, is a medication for the treatment of iron deficiency anemia in adults who have intolerance to oral iron or have had unsatisfactory response to oral iron or who have non-hemodialysis dependent chronic kidney disease (NDD-CKD).^[4] It was approved for use in the United States in January 2020.^[4]^[5]^[6] It is given intravenously.^[4]

References

^ "Monofer iron (as ferric derisomaltose) 1000 mg/10 mL solution for injection vial (290834)". Therapeutic Goods Administration (TGA). 26 May 2022. Archived from the original on 14 April 2023. Retrieved 9 April 2023.
^ "Prescription medicines and biologicals: TGA annual summary 2017". Therapeutic Goods Administration (TGA). 21 June 2022. Archived from the original on 31 March 2024. Retrieved 31 March 2024.
^ "Regulatory Decision Summary for Monoferric". 23 October 2014. Archived from the original on 7 June 2022. Retrieved 7 June 2022.
^ ^a ^b ^c ^d "Monoferric- ferric derisomaltose solution". DailyMed. 24 January 2020. Archived from the original on 1 October 2020. Retrieved 16 February 2020.
^ "Monoferric approval letter" (PDF). U.S. Food and Drug Administration (FDA). 16 January 2020. Archived (PDF) from the original on 17 February 2020. Retrieved 16 February 2020. This article incorporates text from this source, which is in the public domain.
^ "Drug Approval Package: Monoferric Injection". U.S. Food and Drug Administration (FDA). 7 May 2020. Archived from the original on 1 October 2020. Retrieved 13 August 2020.