Formiminoglutamic acid
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Names | |
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IUPAC name N-(aminomethylidene)-L-glutamic acid | |
Other names FIGLU | |
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3D model (JSmol) |
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ECHA InfoCard | 100.011.308 ![]() |
MeSH | Formiminoglutamic+acid |
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Properties | |
Chemical formula | C6H10N2O4 |
Molar mass | 174.156 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ![]() ![]() ![]() Infobox references |
Chemical compound
Formiminoglutamic acid (FIGLU; conjugate base, formiminoglutamate) is an intermediate in the catabolism of L-histidine to L-glutamic acid. It thus is also a biomarker for intracellular levels of folate. The FIGLU test is used to identify vitamin B₁₂ deficiency, folate deficiency, and liver failure or liver disease.[1][2] It is elevated with folate trapping, where it is accompanied by decreased methylmalonic acid, increased folate and a decrease in homocysteine.[3]
See also
- Formiminotransferase cyclodeaminase
- Glutamate-1-semialdehyde
- Glutamic acid
- Imidazol-4-one-5-propionic acid
References
- ^ Lascelles, P. T.; Donaldson, D. (1989). "Formiminoglutamic Acid (FIGLU) Test". Diagnostic Function Tests in Chemical Pathology. pp. 59–60. doi:10.1007/978-94-009-1846-7_31. ISBN 978-0-7462-0107-7.
- ^ FIGLU+Test at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ^ Scott, JohnM.; Weir, DonaldG. (15 August 1981). "THE METHYL FOLATE TRAP: A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid-induced exacerbation of subacute combined degeneration in pernicious anaemia". The Lancet. 318 (8242): 337–340. doi:10.1016/S0140-6736(81)90650-4. ISSN 0140-6736. PMID 6115113. S2CID 29977127.
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lysine→ | |
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leucine→ | |
tryptophan→alanine→ |
G→pyruvate→ citrate |
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G→glutamate→ α-ketoglutarate |
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G→propionyl-CoA→ succinyl-CoA |
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G→fumarate |
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G→oxaloacetate |
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Cysteine metabolism |
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