Fumarylacetoacetic acid

Fumarylacetoacetic acid
Names
Preferred IUPAC name
(2E)-4,6-Dioxooct-2-enedioic acid
Identifiers
CAS Number
  • 28613-33-4 checkY
  • 5698-51-1 checkY
3D model (JSmol)
  • Interactive image
ChemSpider
  • 4444081
MeSH Fumarylacetoacetate
PubChem CID
  • 5280398
UNII
  • FM3BV7K438 checkY
CompTox Dashboard (EPA)
  • DTXSID20901388 Edit this at Wikidata
InChI
  • InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/b2-1+
    Key: GACSIVHAIFQKTC-OWOJBTEDSA-N
  • InChI=1/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/b2-1+
    Key: GACSIVHAIFQKTC-OWOJBTEDBU
  • O=C(\C=C\C(=O)O)CC(=O)CC(=O)O
Properties
Chemical formula
 C8H8O6
Molar mass 200.146 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Chemical compound

Fumarylacetoacetic acid (fumarylacetoacetate) is an intermediate in the metabolism of tyrosine. It is formed through the conversion of maleylacetoacetate into fumarylacetoacetate by the enzyme maleylacetoacetate isomerase.[1]

See also

  • Fumarylacetoacetate hydrolase

References

  1. ^ W. E. Knox and M. LeMay-Knox (1951). "The oxidation in liver of l-tyrosine to acetoacetate through p-hydroxyphenylpyruvate and homogentisic acid". Biochem. J. 49 (5): 686–693. doi:10.1042/bj0490686. PMC 1197578. PMID 14886367.
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