GGL domain

Phosducin - transducin beta-gamma complex. Gamma subunit (GGL domain) colored red.
Identifiers
SymbolG-gamma
PfamPF00631
InterProIPR001770
SMARTGGL
PROSITEPDOC01002
SCOP21gp2 / SCOPe / SUPFAM
OPM protein2bcj
CDDcd00068
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
PDB2bcjG:9-63 1xhmB:9-63 1omwG:9-63

1gp2G:9-60 1gg2G:9-60 2trcG:12-66 1tbgF:12-66 1b9yB:12-66 1b9xB:12-66

1gotG:12-65 1mf6A:59-66

GGL domain is domain found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling RGS proteins.[1]

Human proteins containing this domain

  • GNG4; GNG10; GNG11
  • GNGT1
  • RGS6; RGS7; RGS9; RGS11

See also

References

  1. ^ Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP (1998). "A G protein γ subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gβ5 subunits". Proc. Natl. Acad. Sci. U.S.A. 95 (22): 13307–12. Bibcode:1998PNAS...9513307S. doi:10.1073/pnas.95.22.13307. PMC 23793. PMID 9789084.

Further reading

  • Chatterjee TK, Liu Z, Fisher RA (August 2003). "Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants". J. Biol. Chem. 278 (32): 30261–71. doi:10.1074/jbc.M212687200. PMID 12761221.
  • Chen CK, Eversole-Cire P, Zhang H, et al. (May 2003). "Instability of GGL domain-containing RGS proteins in mice lacking the G protein β-subunit Gβ5". Proc. Natl. Acad. Sci. U.S.A. 100 (11): 6604–9. Bibcode:2003PNAS..100.6604C. doi:10.1073/pnas.0631825100. PMC 164494. PMID 12738888.
  • Liu Z, Chatterjee TK, Fisher RA (October 2002). "RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6". J. Biol. Chem. 277 (40): 37832–9. doi:10.1074/jbc.M205908200. PMID 12140291.


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