HEBP2

Protein-coding gene in the species Homo sapiens
HEBP2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3R85, 3R8J, 3R8K, 4AYZ, 4B0Y

Identifiers
AliasesHEBP2, C6ORF34B, C6orf34, PP23, SOUL, heme binding protein 2
External IDsOMIM: 605825; MGI: 1860084; HomoloGene: 8634; GeneCards: HEBP2; OMA:HEBP2 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for HEBP2
Genomic location for HEBP2
Band6q24.1Start138,403,531 bp[1]
End138,422,197 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for HEBP2
Genomic location for HEBP2
Band10|10 A3Start18,415,246 bp[2]
End18,421,824 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • parotid gland

  • amniotic fluid

  • gums

  • gingival epithelium

  • vulva

  • Skeletal muscle tissue of biceps brachii

  • skin of thigh

  • right ventricle

  • adipose tissue

  • oral cavity
Top expressed in
  • facial motor nucleus

  • esophagus

  • transitional epithelium of urinary bladder

  • skin of external ear

  • skin of abdomen

  • lip

  • epithelium of lens

  • motor neuron

  • conjunctival fornix

  • cornea
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • heme binding
Cellular component
  • cytoplasm
  • extracellular exosome
  • mitochondrion
  • extracellular region
  • azurophil granule lumen
Biological process
  • negative regulation of mitochondrial membrane potential
  • positive regulation of necrotic cell death
  • regulation of response to reactive oxygen species
  • positive regulation of mitochondrial membrane permeability
  • neutrophil degranulation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23593

56016

Ensembl

ENSG00000051620

ENSMUSG00000019853

UniProt

Q9Y5Z4

Q9WU63

RefSeq (mRNA)

NM_014320
NM_001326380
NM_001326381

NM_019487

RefSeq (protein)

NP_001313309
NP_001313310
NP_055135

NP_062360

Location (UCSC)Chr 6: 138.4 – 138.42 MbChr 10: 18.42 – 18.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Heme-binding protein 2 is a protein that in humans is encoded by the HEBP2 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000051620 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019853 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zylka MJ, Reppert SM (Feb 2000). "Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searches". Brain Res Mol Brain Res. 74 (1–2): 175–81. doi:10.1016/S0169-328X(99)00277-6. PMID 10640688.
  6. ^ Szigeti A, Bellyei S, Gasz B, Boronkai A, Hocsak E, Minik O, Bognar Z, Varbiro G, Sumegi B, Gallyas F Jr (Nov 2006). "Induction of necrotic cell death and mitochondrial permeabilization by heme binding protein 2/SOUL". FEBS Lett. 580 (27): 6447–54. doi:10.1016/j.febslet.2006.10.067. PMID 17098234. S2CID 19675303.
  7. ^ "Entrez Gene: HEBP2 heme binding protein 2".

Further reading

  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Liu L, McKeehan WL (2002). "Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity". Genomics. 79 (1): 124–36. doi:10.1006/geno.2001.6679. PMC 3241999. PMID 11827465.
  • Bohn H, Winckler W (1991). "Isolation and characterization of five new soluble placental tissue proteins (PP22, PP23, PP24, PP25, PP26)". Arch. Gynecol. Obstet. 248 (3): 111–5. doi:10.1007/BF02390087. PMID 2018407. S2CID 23535410.


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