IFITM3

Protein-coding gene in the species Homo sapiens
IFITM3
Identifiers
AliasesIFITM3, 1-8U, DSPA2b, IP15, interferon induced transmembrane protein 3
External IDsOMIM: 605579; MGI: 1913391; HomoloGene: 136199; GeneCards: IFITM3; OMA:IFITM3 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for IFITM3
Genomic location for IFITM3
Band11p15.5Start319,676 bp[1]
End329,475 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for IFITM3
Genomic location for IFITM3
Band7|7 F5Start140,589,499 bp[2]
End140,590,683 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left uterine tube

  • Descending thoracic aorta

  • left coronary artery

  • pericardium

  • ascending aorta

  • upper lobe of left lung

  • right coronary artery

  • canal of the cervix

  • right lung

  • body of uterus
Top expressed in
  • aortic valve

  • right lung lobe

  • carotid body

  • granulocyte

  • uterus

  • ascending aorta

  • cervix

  • left lobe of liver

  • calvaria

  • ankle joint
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
Cellular component
  • integral component of membrane
  • endosome
  • membrane
  • late endosome membrane
  • plasma membrane
  • lysosomal membrane
  • lysosome
  • protein-containing complex
Biological process
  • negative regulation of viral entry into host cell
  • response to interferon-gamma
  • immune system process
  • response to virus
  • response to interferon-beta
  • response to biotic stimulus
  • negative regulation of viral genome replication
  • type I interferon signaling pathway
  • immune response
  • response to interferon-alpha
  • innate immune response
  • negative regulation of viral transcription
  • defense response to virus
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10410

66141

Ensembl

ENSG00000142089

ENSMUSG00000025492

UniProt

Q01628

Q9CQW9

RefSeq (mRNA)

NM_021034

NM_025378

RefSeq (protein)

NP_066362

NP_079654

Location (UCSC)Chr 11: 0.32 – 0.33 MbChr 7: 140.59 – 140.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interferon-induced transmembrane protein 3 (IFITM3) is a protein that in humans is encoded by the IFITM3 gene.[5][6][7] It plays a critical role in the immune system's defense against Swine Flu, where heightened levels of IFITM3 keep viral levels low, and the removal of IFITM3 allows the virus to multiply unchecked.[8] This observation has been further advanced by a recent study from Paul Kellam's lab that shows that a single nucleotide polymorphism in the human IFITM3 gene purported to increase influenza susceptibility is overrepresented in people hospitalised with pandemic H1N1.[9] The prevalence of this mutation is thought to be approximately 1/400 in European populations.[9][10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000142089 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025492 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lewin AR, Reid LE, McMahon M, Stark GR, Kerr IM (Aug 1991). "Molecular analysis of a human interferon-inducible gene family". Eur J Biochem. 199 (2): 417–423. doi:10.1111/j.1432-1033.1991.tb16139.x. PMID 1906403.
  6. ^ Tanaka SS, Yamaguchi YL, Tsoi B, Lickert H, Tam PP (Dec 2005). "IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion". Dev Cell. 9 (6): 745–756. doi:10.1016/j.devcel.2005.10.010. PMID 16326387.
  7. ^ "Entrez Gene: IFITM3 interferon induced transmembrane protein 3 (1-8U)".
  8. ^ "Natural swine flu defence found". Archived from the original on December 20, 2009.
  9. ^ a b Everitt A.R.; et al. (March 2012). "IFITM3 restricts the morbidity and mortality associated with influenza". Nature. 484 (7395): 519–23. Bibcode:2012Natur.484..519.. doi:10.1038/nature10921. PMC 3648786. PMID 22446628.
  10. ^ "Gene flaw linked to serious flu risk". BBC News. 25 March 2012.

Further reading

  • Vaarala MH, Porvari K, Kyllönen A, Vihko P (2000). "Differentially expressed genes in two LNCaP prostate cancer cell lines reflecting changes during prostate cancer progression". Lab. Invest. 80 (8): 1259–1268. doi:10.1038/labinvest.3780134. PMID 10950117.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–292. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–D418. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.