IL17RC

Protein-coding gene in the species Homo sapiens
IL17RC
Identifiers
AliasesIL17RC, IL17-RL, IL17RL, CANDF9, interleukin 17 receptor C
External IDsOMIM: 610925; MGI: 2159336; HomoloGene: 15894; GeneCards: IL17RC; OMA:IL17RC - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for IL17RC
Genomic location for IL17RC
Band3p25.3|3p25.3-p24.1Start9,917,074 bp[1]
End9,933,630 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for IL17RC
Genomic location for IL17RC
Band6|6 E3Start113,448,388 bp[2]
End113,460,101 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • anterior pituitary

  • right adrenal cortex

  • right lobe of liver

  • gastric mucosa

  • left adrenal cortex

  • skin of abdomen

  • skin of leg

  • muscle layer of sigmoid colon

  • apex of heart

  • right lobe of thyroid gland
Top expressed in
  • ileum

  • jejunum

  • lip

  • esophagus

  • colon

  • zone of skin

  • urinary bladder

  • white adipose tissue

  • duodenum

  • humerus
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • interleukin-17 receptor activity
  • signaling receptor binding
Cellular component
  • integral component of membrane
  • cell surface
  • integral component of plasma membrane
  • membrane
  • plasma membrane
Biological process
  • positive regulation of cytokine production involved in inflammatory response
  • granulocyte chemotaxis
  • defense response to fungus
  • interleukin-17-mediated signaling pathway
  • cytokine-mediated signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84818

171095

Ensembl

ENSG00000163702

ENSMUSG00000030281

UniProt

Q8NAC3

Q8K4C2

RefSeq (mRNA)
NM_001203263
NM_001203264
NM_001203265
NM_032732
NM_153460

NM_153461
NM_153462
NM_153463
NM_001367278
NM_001367279
NM_001367280

NM_134159
NM_178942

RefSeq (protein)
NP_001190192
NP_001190193
NP_001190194
NP_116121
NP_703190

NP_703191
NP_001354207
NP_001354208
NP_001354209

NP_598920
NP_849273

Location (UCSC)Chr 3: 9.92 – 9.93 MbChr 6: 113.45 – 113.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin-17 receptor C is a protein that in humans is encoded by the IL17RC gene.[5][6]

Function

This gene encodes a single-pass transmembrane protein that shares limited similarity with the interleukin-17 receptor. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, but the full-length nature of only three have been determined to date.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163702 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030281 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Haudenschild D, Moseley T, Rose L, Reddi AH (February 2002). "Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer". The Journal of Biological Chemistry. 277 (6): 4309–16. doi:10.1074/jbc.M109372200. PMID 11706037.
  6. ^ a b "Entrez Gene: IL17RC interleukin 17 receptor C".

Further reading

  • Gerritsen ME, Tomlinson JE, Zlot C, Ziman M, Hwang S (October 2003). "Using gene expression profiling to identify the molecular basis of the synergistic actions of hepatocyte growth factor and vascular endothelial growth factor in human endothelial cells". British Journal of Pharmacology. 140 (4): 595–610. doi:10.1038/sj.bjp.0705494. PMC 1574080. PMID 14504135.
  • Zhang Z, Henzel WJ (October 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
  • Haudenschild DR, Curtiss SB, Moseley TA, Reddi AH (September 2006). "Generation of interleukin-17 receptor-like protein (IL-17RL) in prostate by alternative splicing of RNA". The Prostate. 66 (12): 1268–74. doi:10.1002/pros.20422. PMID 16688746. S2CID 25101473.
  • Toy D, Kugler D, Wolfson M, Vanden Bos T, Gurgel J, Derry J, Tocker J, Peschon J (July 2006). "Cutting edge: interleukin 17 signals through a heteromeric receptor complex". Journal of Immunology. 177 (1): 36–9. doi:10.4049/jimmunol.177.1.36. PMID 16785495.
  • Kuestner RE, Taft DW, Haran A, Brandt CS, Brender T, Lum K, Harder B, Okada S, Ostrander CD, Kreindler JL, Aujla SJ, Reardon B, Moore M, Shea P, Schreckhise R, Bukowski TR, Presnell S, Guerra-Lewis P, Parrish-Novak J, Ellsworth JL, Jaspers S, Lewis KE, Appleby M, Kolls JK, Rixon M, West JW, Gao Z, Levin SD (October 2007). "Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F". Journal of Immunology. 179 (8): 5462–73. doi:10.4049/jimmunol.179.8.5462. PMC 2849293. PMID 17911633.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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