ITIH2

Protein-coding gene in the species Homo sapiens

ITIH2

Identifiers

Aliases

ITIH2, H2P, SHAP, inter-alpha-trypsin inhibitor heavy chain 2

External IDs

OMIM: 146640; MGI: 96619; HomoloGene: 1668; GeneCards: ITIH2; OMA:ITIH2 - orthologs

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	10p14	Start	7,703,316 bp^[1]
Band	10p14	End	7,749,520 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2 A1\|2 6.89 cM	Start	10,099,404 bp^[2]
Band	2 A1\|2 6.89 cM	End	10,136,207 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

liver

right lobe of liver

testicle

Epithelium of choroid plexus

tibialis anterior muscle

cerebellar hemisphere

putamen

right hemisphere of cerebellum

prefrontal cortex

pancreatic ductal cell

Top expressed in

left lobe of liver

gallbladder

fetal liver hematopoietic progenitor cell

human fetus

vestibular membrane of cochlear duct

ankle joint

abdominal wall

sexually immature organism

ascending aorta

optic nerve

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	peptidase inhibitor activity endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity
Cellular component	blood microparticle extracellular exosome extracellular region endoplasmic reticulum lumen collagen-containing extracellular matrix
Biological process	hyaluronan metabolic process negative regulation of peptidase activity negative regulation of endopeptidase activity post-translational protein modification
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3698


16425

Ensembl


ENSG00000151655


ENSMUSG00000037254

UniProt


P19823


Q61703

RefSeq (mRNA)


NM_002216


NM_010582

RefSeq (protein)


NP_002207


NP_034712

Location (UCSC)

Chr 10: 7.7 – 7.75 Mb

Chr 2: 10.1 – 10.14 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Inter-alpha-trypsin inhibitor heavy chain H2 is a protein that in humans is encoded by the ITIH2 gene.^[5]^[6]^[7]

It is known to contain a Gla domain, and thus be dependent for production on post translational modification requiring vitamin K. Its function is also presumably dependent on calcium ions.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151655 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037254 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W, Guenet JL, Mattei MG (Dec 1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily". Genomics. 14 (1): 83–8. doi:10.1016/S0888-7543(05)80287-3. PMID 1385302.
^ Jean L, Risler JL, Nagase T, Coulouarn C, Nomura N, Salier JP (May 1999). "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?". FEBS Lett. 446 (1): 6–8. doi:10.1016/S0014-5793(99)00173-8. PMID 10100603. S2CID 84807160.
^ "Entrez Gene: ITIH2 inter-alpha (globulin) inhibitor H2".

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Salier JP, Diarra-Mehrpour M, Sesboue R, et al. (1988). "Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI". Proc. Natl. Acad. Sci. U.S.A. 84 (23): 8272–6. doi:10.1073/pnas.84.23.8272. PMC 299524. PMID 2446322.
Gebhard W, Schreitmüller T, Hochstrasser K, Wachter E (1988). "Complementary DNA and derived amino acid sequence of the precursor of one of the three protein components of the inter-alpha-trypsin inhibitor complex". FEBS Lett. 229 (1): 63–7. doi:10.1016/0014-5793(88)80798-1. PMID 2450046. S2CID 6539112.
Salier JP, Diarra-Mehrpour M, Sesboüé R, et al. (1989). "Human inter-alpha-trypsin inhibitor. Isolation and characterization of heavy (H) chain cDNA clones coding for a 383 amino-acid sequence of the H chain". Biol. Chem. Hoppe-Seyler. 369 Suppl: 15–8. PMID 2462430.
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Enghild JJ, Thøgersen IB, Pizzo SV, Salvesen G (1989). "Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan". J. Biol. Chem. 264 (27): 15975–81. doi:10.1016/S0021-9258(18)71575-5. PMID 2476436.
Schreitmüller T, Hochstrasser K, Reisinger PW, et al. (1987). "cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins". Biol. Chem. Hoppe-Seyler. 368 (8): 963–70. doi:10.1515/bchm3.1987.368.2.963. PMID 3663330.
Huang L, Yoneda M, Kimata K (1994). "A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor". J. Biol. Chem. 268 (35): 26725–30. doi:10.1016/S0021-9258(19)74373-7. PMID 7504674.
Morelle W, Capon C, Balduyck M, et al. (1994). "Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor". Eur. J. Biochem. 221 (2): 881–8. doi:10.1111/j.1432-1033.1994.tb18803.x. PMID 7513643.
Wisniewski HG, Burgess WH, Oppenheim JD, Vilcek J (1994). "TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor". Biochemistry. 33 (23): 7423–9. doi:10.1021/bi00189a049. PMID 7516184.
Enghild JJ, Salvesen G, Thøgersen IB, et al. (1993). "Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin". J. Biol. Chem. 268 (12): 8711–6. doi:10.1016/S0021-9258(18)52933-1. PMID 7682553.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Mizon C, Balduyck M, Albani D, et al. (1996). "Development of an enzyme-linked immunosorbent assay for human plasma inter-alpha-trypsin inhibitor (ITI) using specific antibodies against each of the H1 and H2 heavy chains". J. Immunol. Methods. 190 (1): 61–70. doi:10.1016/0022-1759(95)00257-X. PMID 8601712.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Olsen EH, Rahbek-Nielsen H, Thogersen IB, et al. (1998). "Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2". Biochemistry. 37 (1): 408–16. doi:10.1021/bi971137d. PMID 9425062.
Mizushima S, Nii A, Kato K, Uemura A (1998). "Gene expression of the two heavy chains and one light chain forming the inter-alpha-trypsin-inhibitor in human tissues". Biol. Pharm. Bull. 21 (2): 167–9. doi:10.1248/bpb.21.167. PMID 9514613.
Flahaut C, Capon C, Balduyck M, et al. (1998). "Glycosylation pattern of human inter-alpha-inhibitor heavy chains". Biochem. J. 333 (3): 749–56. doi:10.1042/bj3330749. PMC 1219641. PMID 9677337.
Hamm A, Veeck J, Bektas N, et al. (2008). "Frequent expression loss of Inter-alpha-trypsin inhibitor heavy chain (ITIH) genes in multiple human solid tumors: a systematic expression analysis". BMC Cancer. 8 (25): 25. doi:10.1186/1471-2407-8-25. PMC 2268946. PMID 18226209.