ITGA2 |
---|
![](//upload.wikimedia.org/wikipedia/commons/thumb/b/b0/Protein_ITGA2_PDB_1aox.png/250px-Protein_ITGA2_PDB_1aox.png) |
Available structures |
---|
PDB | Ortholog search: PDBe RCSB |
---|
List of PDB id codes |
---|
1AOX, 1DZI, 1V7P, 4BJ3 |
|
|
Identifiers |
---|
Aliases | ITGA2, BR, CD49B, GPIa, HPA-5, VLA-2, VLAA2, integrin subunit alpha 2 |
---|
External IDs | OMIM: 192974; MGI: 96600; HomoloGene: 1662; GeneCards: ITGA2; OMA:ITGA2 - orthologs |
---|
Gene location (Human) |
---|
![Chromosome 5 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/6/61/Ideogram_human_chromosome_5.svg/300px-Ideogram_human_chromosome_5.svg.png) | Chr. | Chromosome 5 (human)[1] |
---|
| Band | 5q11.2 | Start | 52,989,340 bp[1] |
---|
End | 53,094,779 bp[1] |
---|
|
Gene location (Mouse) |
---|
![Chromosome 13 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/0/04/Ideogram_house_mouse_chromosome_13.svg/260px-Ideogram_house_mouse_chromosome_13.svg.png) | Chr. | Chromosome 13 (mouse)[2] |
---|
| Band | 13 D2.2|13 64.61 cM | Start | 114,969,617 bp[2] |
---|
End | 115,068,636 bp[2] |
---|
|
RNA expression pattern |
---|
Bgee | Human | Mouse (ortholog) |
---|
Top expressed in | - ventricular zone
- epithelium of nasopharynx
- bronchial epithelial cell
- islet of Langerhans
- visceral pleura
- skin of thigh
- skin of hip
- gingival epithelium
- seminal vesicula
- vulva
|
| Top expressed in | - gastrula
- cumulus cell
- lumbar spinal ganglion
- molar
- blood
- trigeminal ganglion
- Paneth cell
- decidua
- left lung lobe
- stellate reticulum
|
| More reference expression data |
|
---|
BioGPS | |
---|
|
Gene ontology |
---|
Molecular function | - collagen binding
- virus receptor activity
- protein-containing complex binding
- collagen receptor activity
- metal ion binding
- integrin binding
- protein binding
- collagen binding involved in cell-matrix adhesion
- protein heterodimerization activity
- laminin binding
- amyloid-beta binding
- heparan sulfate proteoglycan binding
| Cellular component | - axon terminus
- integral component of membrane
- cell projection
- membrane
- focal adhesion
- basal part of cell
- plasma membrane
- cell surface
- integrin complex
- axon
- integrin alpha2-beta1 complex
- perinuclear region of cytoplasm
- external side of plasma membrane
- nucleus
| Biological process | - positive regulation of collagen biosynthetic process
- positive regulation of inflammatory response
- response to hypoxia
- positive regulation of phagocytosis, engulfment
- skin morphogenesis
- response to organic cyclic compound
- collagen-activated signaling pathway
- positive regulation of leukocyte migration
- establishment of protein localization
- positive regulation of transmission of nerve impulse
- female pregnancy
- cellular response to estradiol stimulus
- cellular response to organic cyclic compound
- hepatocyte differentiation
- positive regulation of epithelial cell migration
- blood coagulation
- extracellular matrix organization
- positive regulation of cell projection organization
- response to L-ascorbic acid
- wound healing
- positive regulation of translation
- substrate-dependent cell migration
- mammary gland development
- positive regulation of smooth muscle cell migration
- focal adhesion assembly
- cell-substrate adhesion
- cellular response to mechanical stimulus
- cell adhesion
- response to parathyroid hormone
- cell adhesion mediated by integrin
- positive regulation of alkaline phosphatase activity
- response to amine
- hypotonic response
- animal organ morphogenesis
- mesodermal cell differentiation
- integrin-mediated signaling pathway
- positive regulation of collagen binding
- viral entry into host cell
- positive regulation of DNA binding
- cell-matrix adhesion
- cell population proliferation
- viral process
- positive regulation of smooth muscle contraction
- response to muscle activity
- positive regulation of cell adhesion
- positive regulation of smooth muscle cell proliferation
- positive regulation of positive chemotaxis
- detection of mechanical stimulus involved in sensory perception of pain
| Sources:Amigo / QuickGO |
|
Orthologs |
---|
Species | Human | Mouse |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (mRNA) | | |
---|
RefSeq (protein) | | |
---|
Location (UCSC) | Chr 5: 52.99 – 53.09 Mb | Chr 13: 114.97 – 115.07 Mb |
---|
PubMed search | [3] | [4] |
---|
|
Wikidata |
View/Edit Human | View/Edit Mouse |
|