KCNC2

Protein-coding gene in humans

KCNC2

Identifiers

Aliases

KCNC2, KV3.2, potassium voltage-gated channel subfamily C member 2

External IDs

OMIM: 176256; MGI: 96668; HomoloGene: 71199; GeneCards: KCNC2; OMA:KCNC2 - orthologs

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q21.1	Start	75,040,077 bp^[1]
Band	12q21.1	End	75,209,839 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10 D2\|10 60.3 cM	Start	112,107,026 bp^[2]
Band	10 D2\|10 60.3 cM	End	112,302,929 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

prefrontal cortex

Brodmann area 9

cingulate gyrus

anterior cingulate cortex

right frontal lobe

testicle

hypothalamus

amygdala

pituitary gland

hippocampus proper

Top expressed in

lateral geniculate nucleus

medial geniculate nucleus

medial dorsal nucleus

inferior colliculus

globus pallidus

superior colliculus

subiculum

primary motor cortex

piriform cortex

medial vestibular nucleus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	potassium channel activity transmembrane transporter binding voltage-gated ion channel activity ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity voltage-gated ion channel activity involved in regulation of presynaptic membrane potential
Cellular component	integral component of membrane vesicle perikaryon postsynaptic membrane cell projection membrane voltage-gated potassium channel complex plasma membrane synapse integral component of plasma membrane intracellular anatomical structure neuronal cell body membrane axon cell junction terminal bouton neuronal cell body dendrite basolateral plasma membrane apical plasma membrane axolemma neuron projection presynaptic membrane dendrite membrane
Biological process	response to organic cyclic compound protein heterooligomerization regulation of insulin secretion response to nerve growth factor regulation of ion transmembrane transport cellular response to toxic substance response to magnesium ion ion transport globus pallidus development nitric oxide-cGMP-mediated signaling pathway potassium ion transport ion transmembrane transport transmembrane transport response to amine positive regulation of potassium ion transmembrane transport cellular response to nitric oxide response to light intensity response to ethanol protein homooligomerization response to toxic substance cellular response to ammonium ion potassium ion transmembrane transport positive regulation of voltage-gated potassium channel activity regulation of presynaptic membrane potential
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3747


268345

Ensembl


ENSG00000166006


ENSMUSG00000035681

UniProt


Q96PR1


Q14B80

RefSeq (mRNA)

NM_001260497 NM_001260498 NM_001260499 NM_139136 NM_139137
NM_153748


NM_001025581 NM_001359752 NM_001359753 NM_001379643 NM_001379644

RefSeq (protein)

NP_001247426 NP_001247427 NP_001247428 NP_631874 NP_631875
NP_715624


NP_001020752 NP_001346681 NP_001346682 NP_001366572 NP_001366573

Location (UCSC)

Chr 12: 75.04 – 75.21 Mb

Chr 10: 112.11 – 112.3 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Potassium voltage-gated channel subfamily C member 2 is a protein that in humans is encoded by the KCNC2 gene.^[5]^[6] The protein encoded by this gene is a voltage-gated potassium channel subunit (Kv3.2).^[7]

Expression pattern

K_v3.1 and K_v3.2 channels are prominently expressed in neurons that fire at high frequency. K_v3.2 channels are prominently expressed in brain (fast-spiking GABAergic interneurons of the neocortex, hippocampus, and caudate nucleus; terminal fields of thalamocortical projections), and in retinal ganglion cells.^[8]^[9]^[7]

Physiological role

K_v3.1/K_v3.2 conductance is necessary and kinetically optimized for high-frequency action potential generation.^[9]^[10] Sometimes in heteromeric complexes with K_v3.1; important for the high-frequency firing of fast spiking GABAergic interneurons and retinal ganglion cells; and GABA release via regulation of action potential duration in presynaptic terminals.^[7]^[8]

Pharmacological properties

K_v3.2 currents in heterologous systems are highly sensitive to external tetraethylammonium (TEA) or 4-aminopyridine (4-AP) (IC₅₀ values are 0.1 mM for both of the drugs).^[7]^[9] This can be useful in identifying native channels.^[9]

Transcript variants

There are four transcript variants of K_v3.2 gene: K_v3.2a, K_v3.2b, K_v3.2c, K_v3.2d. K_v3.2 isoforms differ only in their C-terminal sequence.^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166006 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035681 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Haas M, Ward DC, Lee J, Roses AD, Clarke V, D'Eustachio P, Lau D, Vega-Saenz de Miera E, Rudy B (Mar 1994). "Localization of Shaw-related K+ channel genes on mouse and human chromosomes". Mamm Genome. 4 (12): 711–5. doi:10.1007/BF00357794. PMID 8111118. S2CID 24121259.
^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
^ ^a ^b ^c ^d Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol. Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
^ ^a ^b Kolodin YO (2008-04-27). "Ionic conductances underlying excitability in tonically firing retinal ganglion cells of adult rat". Retrieved 2008-10-20.
^ ^a ^b ^c ^d Rudy B, McBain CJ (September 2001). "K_v3 channels: voltage-gated K⁺ channels designed for high-frequency repetitive firing". Trends in Neurosciences. 24 (9): 517–26. doi:10.1016/S0166-2236(00)01892-0. PMID 11506885. S2CID 36100588.
^ Lien CC, Jonas P (March 2003). "K_v3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons". Journal of Neuroscience. 23 (6): 2058–68. doi:10.1523/JNEUROSCI.23-06-02058.2003. PMC 6742035. PMID 12657664.
^ Rudy B, Chow A, Lau D, Amarillo Y, Ozaita A, Saganich M, Moreno H, Nadal MS, Hernandez-Pineda R, Hernandez-Cruz A, Erisir A, Leonard C, Vega-Saenz de Miera E (April 1999). "Contributions of K_v3 channels to neuronal excitability". Annals of the New York Academy of Sciences. 868 (1 MOLECULAR AND): 304–43. Bibcode:1999NYASA.868..304R. doi:10.1111/j.1749-6632.1999.tb11295.x. PMID 10414303. S2CID 25289187.

External links

Kv3.2+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
KCNC2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin