Protein-coding gene in humans
KCNC2 |
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Identifiers |
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Aliases | KCNC2, KV3.2, potassium voltage-gated channel subfamily C member 2 |
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External IDs | OMIM: 176256; MGI: 96668; HomoloGene: 71199; GeneCards: KCNC2; OMA:KCNC2 - orthologs |
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Gene location (Human) |
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![Chromosome 12 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/e/e7/Ideogram_human_chromosome_12.svg/300px-Ideogram_human_chromosome_12.svg.png) | Chr. | Chromosome 12 (human)[1] |
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| Band | 12q21.1 | Start | 75,040,077 bp[1] |
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End | 75,209,839 bp[1] |
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Gene location (Mouse) |
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![Chromosome 10 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Ideogram_house_mouse_chromosome_10.svg/260px-Ideogram_house_mouse_chromosome_10.svg.png) | Chr. | Chromosome 10 (mouse)[2] |
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| Band | 10 D2|10 60.3 cM | Start | 112,107,026 bp[2] |
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End | 112,302,929 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - prefrontal cortex
- Brodmann area 9
- cingulate gyrus
- anterior cingulate cortex
- right frontal lobe
- testicle
- hypothalamus
- amygdala
- pituitary gland
- hippocampus proper
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| Top expressed in | - lateral geniculate nucleus
- medial geniculate nucleus
- medial dorsal nucleus
- inferior colliculus
- globus pallidus
- superior colliculus
- subiculum
- primary motor cortex
- piriform cortex
- medial vestibular nucleus
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - potassium channel activity
- transmembrane transporter binding
- voltage-gated ion channel activity
- ion channel activity
- voltage-gated potassium channel activity
- delayed rectifier potassium channel activity
- voltage-gated ion channel activity involved in regulation of presynaptic membrane potential
| Cellular component | - integral component of membrane
- vesicle
- perikaryon
- postsynaptic membrane
- cell projection
- membrane
- voltage-gated potassium channel complex
- plasma membrane
- synapse
- integral component of plasma membrane
- intracellular anatomical structure
- neuronal cell body membrane
- axon
- cell junction
- terminal bouton
- neuronal cell body
- dendrite
- basolateral plasma membrane
- apical plasma membrane
- axolemma
- neuron projection
- presynaptic membrane
- dendrite membrane
| Biological process | - response to organic cyclic compound
- protein heterooligomerization
- regulation of insulin secretion
- response to nerve growth factor
- regulation of ion transmembrane transport
- cellular response to toxic substance
- response to magnesium ion
- ion transport
- globus pallidus development
- nitric oxide-cGMP-mediated signaling pathway
- potassium ion transport
- ion transmembrane transport
- transmembrane transport
- response to amine
- positive regulation of potassium ion transmembrane transport
- cellular response to nitric oxide
- response to light intensity
- response to ethanol
- protein homooligomerization
- response to toxic substance
- cellular response to ammonium ion
- potassium ion transmembrane transport
- positive regulation of voltage-gated potassium channel activity
- regulation of presynaptic membrane potential
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | NM_001260497 NM_001260498 NM_001260499 NM_139136 NM_139137
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NM_153748 |
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NM_001025581 NM_001359752 NM_001359753 NM_001379643 NM_001379644 |
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RefSeq (protein) | NP_001247426 NP_001247427 NP_001247428 NP_631874 NP_631875
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NP_715624 |
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NP_001020752 NP_001346681 NP_001346682 NP_001366572 NP_001366573 |
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Location (UCSC) | Chr 12: 75.04 – 75.21 Mb | Chr 10: 112.11 – 112.3 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Potassium voltage-gated channel subfamily C member 2 is a protein that in humans is encoded by the KCNC2 gene.[5][6] The protein encoded by this gene is a voltage-gated potassium channel subunit (Kv3.2).[7]
Expression pattern
Kv3.1 and Kv3.2 channels are prominently expressed in neurons that fire at high frequency. Kv3.2 channels are prominently expressed in brain (fast-spiking GABAergic interneurons of the neocortex, hippocampus, and caudate nucleus; terminal fields of thalamocortical projections), and in retinal ganglion cells.[8][9][7]
Physiological role
Kv3.1/Kv3.2 conductance is necessary and kinetically optimized for high-frequency action potential generation.[9][10] Sometimes in heteromeric complexes with Kv3.1; important for the high-frequency firing of fast spiking GABAergic interneurons and retinal ganglion cells; and GABA release via regulation of action potential duration in presynaptic terminals.[7][8]
Pharmacological properties
Kv3.2 currents in heterologous systems are highly sensitive to external tetraethylammonium (TEA) or 4-aminopyridine (4-AP) (IC50 values are 0.1 mM for both of the drugs).[7][9] This can be useful in identifying native channels.[9]
Transcript variants
There are four transcript variants of Kv3.2 gene: Kv3.2a, Kv3.2b, Kv3.2c, Kv3.2d. Kv3.2 isoforms differ only in their C-terminal sequence.[11]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000166006 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035681 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Haas M, Ward DC, Lee J, Roses AD, Clarke V, D'Eustachio P, Lau D, Vega-Saenz de Miera E, Rudy B (Mar 1994). "Localization of Shaw-related K+ channel genes on mouse and human chromosomes". Mamm Genome. 4 (12): 711–5. doi:10.1007/BF00357794. PMID 8111118. S2CID 24121259.
- ^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
- ^ a b c d Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol. Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
- ^ a b Kolodin YO (2008-04-27). "Ionic conductances underlying excitability in tonically firing retinal ganglion cells of adult rat". Retrieved 2008-10-20.
- ^ a b c d Rudy B, McBain CJ (September 2001). "Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing". Trends in Neurosciences. 24 (9): 517–26. doi:10.1016/S0166-2236(00)01892-0. PMID 11506885. S2CID 36100588.
- ^ Lien CC, Jonas P (March 2003). "Kv3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons". Journal of Neuroscience. 23 (6): 2058–68. doi:10.1523/JNEUROSCI.23-06-02058.2003. PMC 6742035. PMID 12657664.
- ^ Rudy B, Chow A, Lau D, Amarillo Y, Ozaita A, Saganich M, Moreno H, Nadal MS, Hernandez-Pineda R, Hernandez-Cruz A, Erisir A, Leonard C, Vega-Saenz de Miera E (April 1999). "Contributions of Kv3 channels to neuronal excitability". Annals of the New York Academy of Sciences. 868 (1 MOLECULAR AND): 304–43. Bibcode:1999NYASA.868..304R. doi:10.1111/j.1749-6632.1999.tb11295.x. PMID 10414303. S2CID 25289187.
External links
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