KSR1 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/9/96/Protein_KSR1_PDB_1kbe.png/250px-Protein_KSR1_PDB_1kbe.png) |
Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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1KBE, 1KBF, 2LPE |
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Identifiers |
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Aliases | KSR1, KSR, RSU2, kinase suppressor of ras 1 |
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External IDs | OMIM: 601132; MGI: 105051; HomoloGene: 8410; GeneCards: KSR1; OMA:KSR1 - orthologs |
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Gene location (Human) |
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![Chromosome 17 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/0/00/Ideogram_human_chromosome_17.svg/300px-Ideogram_human_chromosome_17.svg.png) | Chr. | Chromosome 17 (human)[1] |
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| Band | 17q11.2 | Start | 27,456,448 bp[1] |
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End | 27,626,438 bp[1] |
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Gene location (Mouse) |
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![Chromosome 11 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Ideogram_house_mouse_chromosome_11.svg/260px-Ideogram_house_mouse_chromosome_11.svg.png) | Chr. | Chromosome 11 (mouse)[2] |
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| Band | 11 B5|11 46.74 cM | Start | 78,904,266 bp[2] |
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End | 79,037,233 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - body of pancreas
- sural nerve
- oocyte
- right lobe of thyroid gland
- canal of the cervix
- left lobe of thyroid gland
- gallbladder
- ectocervix
- left testis
- left ovary
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| Top expressed in | - muscle of thigh
- temporal muscle
- triceps brachii muscle
- dentate gyrus of hippocampal formation granule cell
- digastric muscle
- medial head of gastrocnemius muscle
- sternocleidomastoid muscle
- quadriceps femoris muscle
- granulocyte
- vastus lateralis muscle
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/7/7f/PBB_GE_KSR1_213769_at_fs.png/250px-PBB_GE_KSR1_213769_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/c/cc/PBB_GE_KSR1_213767_at_fs.png/250px-PBB_GE_KSR1_213767_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - metal ion binding
- protein C-terminus binding
- protein binding
- ATP binding
- MAP-kinase scaffold activity
- protein kinase activity
- signal transducer activity
- mitogen-activated protein kinase kinase binding
- chaperone binding
- Hsp90 protein binding
- 14-3-3 protein binding
| Cellular component | - cytoplasm
- cytosol
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
- cell projection
- ruffle membrane
- plasma membrane
- protein-containing complex
| Biological process | - intracellular signal transduction
- MAPK cascade
- cAMP-mediated signaling
- protein phosphorylation
- Ras protein signal transduction
- positive regulation of MAPK cascade
- regulation of cell population proliferation
- regulation of MAP kinase activity
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_014238 NM_001367810 NM_001394583 NM_001394584 NM_001394585 |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 17: 27.46 – 27.63 Mb | Chr 11: 78.9 – 79.04 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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