Protein-coding gene in the species Homo sapiens
LCTL |
---|
|
Identifiers |
---|
Aliases | LCTL, KLG, KLPH, lactase like |
---|
External IDs | OMIM: 617060; MGI: 2183549; HomoloGene: 70710; GeneCards: LCTL; OMA:LCTL - orthologs |
---|
Gene location (Human) |
---|
| Chr. | Chromosome 15 (human)[1] |
---|
| Band | 15q22.31 | Start | 66,547,179 bp[1] |
---|
End | 66,565,998 bp[1] |
---|
|
Gene location (Mouse) |
---|
| Chr. | Chromosome 9 (mouse)[2] |
---|
| Band | 9|9 C | Start | 64,024,429 bp[2] |
---|
End | 64,045,400 bp[2] |
---|
|
RNA expression pattern |
---|
Bgee | Human | Mouse (ortholog) |
---|
Top expressed in | - sural nerve
- testicle
- C1 segment
- gonad
- stromal cell of endometrium
- caudate nucleus
- nucleus accumbens
- amygdala
- ventricular zone
- putamen
|
| Top expressed in | - lens
- white adipose tissue
- morula
- blastocyst
- right kidney
- human kidney
- primary oocyte
- ovary
- secondary oocyte
- skeletal muscle tissue
|
| More reference expression data |
|
---|
BioGPS | |
---|
|
Gene ontology |
---|
Molecular function | - hydrolase activity, hydrolyzing O-glycosyl compounds
- beta-glucosidase activity
| Cellular component | - integral component of membrane
- endoplasmic reticulum membrane
- brush border
- membrane
- endoplasmic reticulum
| Biological process | - glycosyl compound metabolic process
- carbohydrate metabolic process
- lens morphogenesis in camera-type eye
- visual perception
- response to stimulus
| Sources:Amigo / QuickGO |
|
Orthologs |
---|
Species | Human | Mouse |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (mRNA) | |
---|
NM_001278562 NM_207338 NM_001394632 NM_001394633 |
| |
---|
RefSeq (protein) | | |
---|
Location (UCSC) | Chr 15: 66.55 – 66.57 Mb | Chr 9: 64.02 – 64.05 Mb |
---|
PubMed search | [3] | [4] |
---|
|
Wikidata |
View/Edit Human | View/Edit Mouse |
|
Lactase-like is a protein that in humans is encoded by the LCTL gene.[5] Lactase-like is a glycosidase enzyme.
Function
This gene encodes a member of family 1 glycosidases. Glycosidases are enzymes that hydrolyze glycosidic bonds and are classified into families based on primary amino acid sequence. Most members of family 1 have two conserved glutamic acid residues, which are required for enzymatic activity. The mouse ortholog of this protein has been characterized and has a domain structure of an N-terminal signal peptide, glycosidase domain, transmembrane domain, and a short cytoplasmic tail. It lacks one of the conserved glutamic acid residues important for catalysis, and its function remains to be determined (PMID: 12084582). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000188501 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032401 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Lactase-like". Retrieved 2013-09-25.
Further reading
- Kim J, Eskiocak U, Stadler G, Lou Z, Kuro-o M, Shay JW, Wright WE (December 2011). "Short hairpin RNA screen indicates that Klotho beta/FGF19 protein overcomes stasis in human colonic epithelial cells". The Journal of Biological Chemistry. 286 (50): 43294–300. doi:10.1074/jbc.M111.267641. PMC 3234855. PMID 22020932.
- Mian IS (June 1998). "Sequence, structural, functional, and phylogenetic analyses of three glycosidase families". Blood Cells, Molecules & Diseases. 24 (2): 83–100. doi:10.1006/bcmd.1998.9998. PMID 9779294.
- Ito S, Fujimori T, Hayashizaki Y, Nabeshima Y (July 2002). "Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical active site structure". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1576 (3): 341–5. doi:10.1016/S0167-4781(02)00281-6. PMID 12084582.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.