LGR4 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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4KT1, 4QXE, 4QXF |
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Identifiers |
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Aliases | LGR4, BNMD17, GPR48, leucine-rich repeat containing G protein-coupled receptor 4, leucine rich repeat containing G protein-coupled receptor 4, DPSL |
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External IDs | OMIM: 606666; MGI: 1891468; HomoloGene: 10226; GeneCards: LGR4; OMA:LGR4 - orthologs |
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Gene location (Human) |
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![Chromosome 11 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Ideogram_human_chromosome_11.svg/300px-Ideogram_human_chromosome_11.svg.png) | Chr. | Chromosome 11 (human)[1] |
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| Band | 11p14.1 | Start | 27,365,961 bp[1] |
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End | 27,472,790 bp[1] |
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Gene location (Mouse) |
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![Chromosome 2 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/b/bb/Ideogram_house_mouse_chromosome_2.svg/260px-Ideogram_house_mouse_chromosome_2.svg.png) | Chr. | Chromosome 2 (mouse)[2] |
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| Band | 2|2 E3 | Start | 109,747,992 bp[2] |
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End | 109,844,602 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - body of pancreas
- hair follicle
- gingival epithelium
- rectum
- decidua
- mucosa of colon
- mucosa of sigmoid colon
- Epithelium of choroid plexus
- metanephros
- metanephric glomerulus
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| Top expressed in | - hand
- otolith organ
- epithelium of lens
- utricle
- renal corpuscle
- ciliary body
- Gonadal ridge
- left colon
- epithelium of stomach
- migratory enteric neural crest cell
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/2/2d/PBB_GE_LGR4_218326_s_at_fs.png/250px-PBB_GE_LGR4_218326_s_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - signal transducer activity
- protein binding
- transmembrane signaling receptor activity
- G protein-coupled receptor activity
- protein-hormone receptor activity
- G protein-coupled peptide receptor activity
| Cellular component | - integral component of membrane
- membrane
- integral component of plasma membrane
- plasma membrane
| Biological process | - hair follicle development
- G protein-coupled receptor signaling pathway
- cell differentiation
- positive regulation of branching involved in ureteric bud morphogenesis
- male genitalia development
- metanephric nephron tubule morphogenesis
- rhythmic process
- metanephric glomerulus development
- immune system process
- epithelial cell proliferation
- Wnt signaling pathway
- tube morphogenesis
- positive regulation of transcription, DNA-templated
- multicellular organism development
- cell differentiation involved in metanephros development
- intestinal stem cell homeostasis
- epithelial cell proliferation involved in renal tubule morphogenesis
- circadian rhythm
- canonical Wnt signaling pathway involved in metanephric kidney development
- digestive tract development
- innate immune response
- negative regulation of transcription, DNA-templated
- signal transduction
- positive regulation of canonical Wnt signaling pathway
- bone remodeling
- circadian regulation of gene expression
- spermatogenesis
- osteoblast differentiation
- bone mineralization
- negative regulation of toll-like receptor signaling pathway
- adenylate cyclase-activating G protein-coupled receptor signaling pathway
- activation of adenylate cyclase activity
- hormone-mediated signaling pathway
- negative regulation of cold-induced thermogenesis
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 11: 27.37 – 27.47 Mb | Chr 2: 109.75 – 109.84 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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