LILRA4

Protein-coding gene in the species Homo sapiens
LILRA4
Identifiers
AliasesLILRA4, CD85g, ILT7, leukocyte immunoglobulin like receptor A4
External IDsOMIM: 607517; HomoloGene: 69118; GeneCards: LILRA4; OMA:LILRA4 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for LILRA4
Genomic location for LILRA4
Band19q13.42Start54,333,185 bp[1]
End54,339,162 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • spleen

  • testicle

  • lymph node

  • monocyte

  • blood

  • appendix

  • C1 segment

  • gonad

  • substantia nigra
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • signaling receptor binding
  • coreceptor activity
Cellular component
  • membrane
  • integral component of membrane
  • integral component of plasma membrane
  • Fc-epsilon receptor I complex
  • plasma membrane
Biological process
  • immune system process
  • negative regulation of interferon-alpha production
  • negative regulation of tumor necrosis factor production
  • negative regulation of toll-like receptor 7 signaling pathway
  • negative regulation of toll-like receptor 9 signaling pathway
  • Fc-epsilon receptor signaling pathway
  • innate immune response
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23547

n/a

Ensembl

ENSG00000277092
ENSG00000276798
ENSG00000274185
ENSG00000239961

n/a

UniProt

P59901

n/a

RefSeq (mRNA)

NM_012276

n/a

RefSeq (protein)

NP_036408

n/a

Location (UCSC)Chr 19: 54.33 – 54.34 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Leukocyte immunoglobulin-like receptor subfamily A member 4 (LILR-A5) also known as CD85 antigen-like family member G (CD85g), and immunoglobulin-like transcript 7 (ILT-7) is a protein that in humans is encoded by the LILRA4 gene.[3][4]

This gene encodes an immunoglobulin-like cell surface protein preferentially expressed in plasmacytoid dendritic cells (PDCs). This gene is highly expressed in PDCs, and is found to be rapidly down-regulated by interleukin 3 (IL3). This gene is one of the 19 highly related genes that form a leukocyte immunoglobulin-like receptor gene cluster (LRC) at chromosomal region 19q13.4.[4]

References

  1. ^ a b c ENSG00000276798, ENSG00000274185, ENSG00000239961 GRCh38: Ensembl release 89: ENSG00000277092, ENSG00000276798, ENSG00000274185, ENSG00000239961 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Wende H, Volz A, Ziegler A (Sep 2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID 10941842. S2CID 20719684.
  4. ^ a b "Entrez Gene: LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4".

Further reading

  • Cho M, Ishida K, Chen J, et al. (2008). "SAGE library screening reveals ILT7 as a specific plasmacytoid dendritic cell marker that regulates type I IFN production". Int. Immunol. 20 (1): 155–64. doi:10.1093/intimm/dxm127. PMID 18048391.
  • Sellick GS, Wade R, Richards S, et al. (2008). "Scan of 977 nonsynonymous SNPs in CLL4 trial patients for the identification of genetic variants influencing prognosis". Blood. 111 (3): 1625–33. doi:10.1182/blood-2007-08-110130. PMID 18006695.
  • Zhan X, Desiderio DM (2006). "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry". Anal. Biochem. 354 (2): 279–89. doi:10.1016/j.ab.2006.05.024. PMID 16777052.
  • Cao W, Rosen DB, Ito T, et al. (2006). "Plasmacytoid dendritic cell–specific receptor ILT7–FcɛRIγ inhibits Toll-like receptor–induced interferon production". J. Exp. Med. 203 (6): 1399–405. doi:10.1084/jem.20052454. PMC 2118323. PMID 16735691.
  • Ju XS, Hacker C, Scherer B, et al. (2004). "Immunoglobulin-like transcripts ILT2, ILT3 and ILT7 are expressed by human dendritic cells and down-regulated following activation". Gene. 331: 159–64. doi:10.1016/j.gene.2004.02.018. PMID 15094202.
  • Tedla N, Bandeira-Melo C, Tassinari P, et al. (2003). "Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7". Proc. Natl. Acad. Sci. U.S.A. 100 (3): 1174–9. Bibcode:2003PNAS..100.1174T. doi:10.1073/pnas.0337567100. PMC 298746. PMID 12529506.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Rissoan MC, Duhen T, Bridon JM, et al. (2002). "Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells". Blood. 100 (9): 3295–303. doi:10.1182/blood-2002-02-0638. PMID 12384430.
  • Young NT, Canavez F, Uhrberg M, et al. (2001). "Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex". Immunogenetics. 53 (4): 270–8. doi:10.1007/s002510100332. PMID 11491530. S2CID 2819935.