LIMS2

Protein-coding gene in the species Homo sapiens
LIMS2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3IXE

Identifiers
AliasesLIMS2, PINCH-2, PINCH2, LGMD2W, LIM zinc finger domain containing 2, MDRCMTT
External IDsOMIM: 607908; MGI: 2385067; HomoloGene: 41214; GeneCards: LIMS2; OMA:LIMS2 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for LIMS2
Genomic location for LIMS2
Band2q14.3Start127,638,381 bp[1]
End127,681,786 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for LIMS2
Genomic location for LIMS2
Band18|18 B1Start32,055,343 bp[2]
End32,091,672 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • apex of heart

  • muscle layer of sigmoid colon

  • body of uterus

  • right coronary artery

  • popliteal artery

  • tibial arteries

  • ascending aorta

  • Descending thoracic aorta

  • left coronary artery

  • right lung
Top expressed in
  • tunica media of zone of aorta

  • interventricular septum

  • ascending aorta

  • right lung lobe

  • sciatic nerve

  • left lobe of liver

  • belly cord

  • spermatocyte

  • aortic valve

  • myocardium of ventricle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • metal ion binding
Cellular component
  • cytosol
  • cell junction
  • plasma membrane
  • membrane
  • nucleus
  • focal adhesion
  • cytoplasm
  • cell-cell junction
Biological process
  • positive regulation of integrin-mediated signaling pathway
  • negative regulation of neural precursor cell proliferation
  • cell-cell junction organization
  • negative regulation of apoptotic process
  • negative regulation of hepatocyte proliferation
  • cell junction assembly
  • negative regulation of epithelial cell proliferation
  • cell-cell adhesion
  • positive regulation of substrate adhesion-dependent cell spreading
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55679

225341

Ensembl

ENSG00000072163

ENSMUSG00000024395

UniProt

Q7Z4I7

Q91XD2

RefSeq (mRNA)

NM_001136037
NM_001161403
NM_001161404
NM_001256542
NM_017980

NM_144862
NM_001365015
NM_001379137
NM_001379138

RefSeq (protein)

NP_001129509
NP_001154875
NP_001154876
NP_001243471
NP_060450

NP_659111
NP_001351944
NP_001366066
NP_001366067

Location (UCSC)Chr 2: 127.64 – 127.68 MbChr 18: 32.06 – 32.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

LIM zinc finger domain containing 2 is a protein that in humans is encoded by the LIMS2 gene. [5]

Function

This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein has five LIM domains, each domain forming two zinc fingers, which permit interactions which regulate cell shape and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000072163 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024395 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: LIM zinc finger domain containing 2". Retrieved 2017-11-06.

Further reading

  • Zhang Y, Chen K, Guo L, Wu C (2002). "Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration". J. Biol. Chem. 277 (41): 38328–38. doi:10.1074/jbc.M205576200. PMID 12167643.
  • Kim SK, Jang HR, Kim JH, Noh SM, Song KS, Kim MR, Kim SY, Yeom YI, Kim NS, Yoo HS, Kim YS (2006). "The epigenetic silencing of LIMS2 in gastric cancer and its inhibitory effect on cell migration". Biochem. Biophys. Res. Commun. 349 (3): 1032–40. doi:10.1016/j.bbrc.2006.08.128. PMID 16959213.
  • Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
  • Yuan Y, Dong HP, Nymoen DA, Nesland JM, Wu C, Davidson B (2011). "PINCH-2 expression in cancers involving serosal effusions using quantitative PCR". Cytopathology. 22 (1): 22–9. doi:10.1111/j.1365-2303.2010.00757.x. PMC 3225403. PMID 20500520.
  • Park CH, Rha SY, Ahn JB, Shin SJ, Kwon WS, Kim TS, An S, Kim NK, Yang WI, Chung HC (2015). "PINCH-2 presents functional copy number variation and suppresses migration of colon cancer cells by paracrine activity". Int. J. Cancer. 136 (10): 2273–83. doi:10.1002/ijc.29273. PMID 25346044. S2CID 2850271.
  • Chardon JW, Smith AC, Woulfe J, Pena E, Rakhra K, Dennie C, Beaulieu C, Huang L, Schwartzentruber J, Hawkins C, Harms MB, Dojeiji S, Zhang M, Majewski J, Bulman DE, Boycott KM, Dyment DA (2015). "LIMS2 mutations are associated with a novel muscular dystrophy, severe cardiomyopathy and triangular tongues". Clin. Genet. 88 (6): 558–64. doi:10.1111/cge.12561. PMID 25589244. S2CID 23714774.


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This article incorporates text from the United States National Library of Medicine, which is in the public domain.