Protein family
The leukotriene (LT) receptors are G protein-coupled receptors that bind and are activated by the leukotrienes. They include the following proteins:
- Leukotriene B4 receptors (BLTRs) – bind to and are activated by LTB4:
- BLT1 (Leukotriene B4 receptor 1) – LTB4R
- BLT2 (Leukotriene B4 receptor 2) – LTB4R2
- Cysteinyl leukotriene receptors (CysLTRs) – bind to and are activated by LTC4, LTD4, and LTE4:
- CysLT1 (Cysteinyl leukotriene receptor 1) – CYSLTR1
- CysLT2 (Cysteinyl leukotriene receptor 2) – CYSLTR2
The recently elucidated CysLTE, represented by GPR99/OXGR1, may constitute a third CysLTR.[1]
See also
- Eicosanoid receptor
- Oxoeicosanoid receptor
- Prostaglandin receptor
- Thromboxane receptor
References
- ^ Kanaoka Y, Maekawa A, Austen KF (2013). "Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand". J. Biol. Chem. 288 (16): 10967–72. doi:10.1074/jbc.C113.453704. PMC 3630866. PMID 23504326.
External links
- IUPHAR GPCR Database – Leukotriene receptors
- Leukotriene+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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Receptor (ligands) | BLTTooltip Leukotriene B4 receptor | BLT1Tooltip Leukotriene B4 receptor 1 | - Agonists: 12-HETE
- 20-Hydroxy-LTB4
- Leukotriene B4
- LY-255283
- Antagonists: 20-Carboxy-LTB4
- Amelubant
- CGS-23131 (LY-223982)
- CGS-25019C
- CP-105696
- CP-195543
- Etalocib
- LY-293111
- Moxilubant
- ONO-4057
- RG-14893
- RP-69698
- SB-209247
- SC-53228
- Ticolubant
- U-75302
- ZK-158252
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BLT2Tooltip Leukotriene B4 receptor 2 | - Antagonists: CP-195543
- LY-255283
- ZK-158252
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CysLTTooltip Cysteinyl leukotriene receptor | CysLT1Tooltip Cysteinyl leukotriene receptor 1 | - Agonists: Leukotriene C4
- Leukotriene D4
- Leukotriene E4
- Antagonists: Ablukast
- BAYu9773
- BAYu9916
- BAYx7195
- Cinalukast
- FPL-55712
- ICI-198615
- Iralukast
- LY-170680
- Masilukast
- MK-571
- Montelukast
- ONO-1078
- Pobilukast
- Pranlukast
- Ritolukast
- SKF-104353
- SR-2640
- Sulukast
- Tipelukast
- Tomelukast
- Verlukast
- Zafirlukast
- ZD-3523
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CysLT2Tooltip Cysteinyl leukotriene receptor 2 | - Agonists: Leukotriene C4
- Leukotriene D4
- Leukotriene E4
- Antagonists: BAYu9773
- BAYu9916
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CysLTETooltip Cysteinyl leukotriene receptor E | |
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Enzyme (inhibitors) | 5-LOXTooltip Arachidonate 5-lipoxygenase | - FLAPTooltip Arachidonate 5-lipoxygenase-activating protein inhibitors: AM-103
- AM-679
- BAYx1005
- MK-591
- MK-886
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12-LOXTooltip Arachidonate 12-lipoxygenase | |
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15-LOXTooltip Arachidonate 15-lipoxygenase | |
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LTA4HTooltip Leukotriene A4 hydrolase | |
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LTB4HTooltip Leukotriene B4 ω-hydroxylase | |
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LTC4STooltip Leukotriene C4 synthase | |
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LTC4HTooltip Leukotriene C4 hydrolase | |
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LTD4Tooltip Leukotriene D4 hydrolase | |
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Others | |
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- See also
- Receptor/signaling modulators
- Prostanoid signaling modulators
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