Lysophosphatidic acid receptor

The lysophosphatidic acid receptors (LPARs) are a group of G protein-coupled receptors for lysophosphatidic acid (LPA) that include:

Lysophosphatidic acid receptor 1 (LPAR1; formerly known as EDG2, GPR26)
Lysophosphatidic acid receptor 2 (LPAR2; formerly known as EDG4)
Lysophosphatidic acid receptor 3 (LPAR3; formerly known as EDG7)
Lysophosphatidic acid receptor 4 (LPAR4; formerly known as GPR23, P2RY9)
Lysophosphatidic acid receptor 5 (LPAR5; formerly known as GPR92)
Lysophosphatidic acid receptor 6 (LPAR6; formerly known as GPR87, P2RY5)

References

Membrane proteins, receptors: cell surface receptors

G protein-coupled receptor

Class A	Eicosanoid receptor (Prostaglandin receptor) Protease-activated receptor Neurotransmitter receptor Purinergic receptor Biogenic amine receptor Olfactory receptor
Class B	Secretin receptor
Class C	Metabotropic glutamate receptor
Class D	Pheromone receptor
Class E	cAMP receptor
Class F	Frizzled/smoothened

Other/ungrouped

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2), EP (1 2 3 4), FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Other

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

Extracellular

Eicosanoids	Classic: Eoxins; Leukotrienes (LTR) Prostacyclin (IPR) Prostaglandins (PGR) Thromboxane (TXR) Nonclassic: EETs Endocannabinoids (CBR) Epi-lipoxins (FPR2) Hepoxilins Isoprostanes Lipoxins (FPR2) Oxoeicosanoids (OXER) Resolvins (FPR2)
Lysophospholipids	LPA (LPAR) S1P (S1PR)
Steroids	Bile acids (GPBAR) Neurosteroids Pheromones (VNR)
Others	PAF (PAFR) Retinal (RHO)

Intracellular

Nuclear receptor	Steroids: Sex steroids: Androgens (AR) Estrogens (ER) Progestogens (PR); Corticosteroids: Glucocorticoids (GR) Mineralocorticoids (MR); Others: Bile acids (FXR) Calcitriol (VDR); Others: Eicosanoids (PPAR) Free fatty acids (PPAR) Retinoic acid (RAR, RXR)
Second messenger	General: Arachidonic acid DAG (PKC, TRPC) IP₃ (IP₃R, RyR) Phosphatidic acid Phosphoinositides: PIP₂ (IRKs) PIP₃ (PKB/Akt, Btk, PDPK1) PtdIns(3,4)P₂ (PKB/Akt, PDPK1); Sphingolipids: C1P Ceramide (CAPPs, KSR1, PKCζ, CTSD) Glucosylceramides S1P Sphingosine (SDK1, PKH, YPK)