MAP4K3

Protein-coding gene in the species Homo sapiens

MAP4K3

Identifiers

Aliases

MAP4K3, GLK, MAPKKKK3, MEKKK 3, MEKKK3, RAB8IPL1, mitogen-activated protein kinase kinase kinase kinase 3

External IDs

OMIM: 604921; MGI: 2154405; HomoloGene: 2683; GeneCards: MAP4K3; OMA:MAP4K3 - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2p22.1	Start	39,249,266 bp^[1]
Band	2p22.1	End	39,437,301 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	17\|17 E3	Start	80,580,512 bp^[2]
Band	17\|17 E3	End	80,728,485 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

secondary oocyte

Achilles tendon

sural nerve

Skeletal muscle tissue of rectus abdominis

tibia

epithelium of colon

gastrocnemius muscle

biceps brachii

endometrium

jejunum

Top expressed in

vestibular membrane of cochlear duct

epithelium of lens

Paneth cell

left lung lobe

retina

calvaria

Region I of hippocampus proper

fossa

vestibular sensory epithelium

cingulate gyrus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	transferase activity protein kinase activity protein serine/threonine kinase activity nucleotide binding protein binding ATP binding kinase activity MAP kinase kinase kinase kinase activity
Cellular component	cytoplasm
Biological process	response to tumor necrosis factor protein phosphorylation JNK cascade intracellular signal transduction response to UV phosphorylation regulation of mitotic cell cycle regulation of apoptotic process signal transduction stress-activated protein kinase signaling cascade activation of protein kinase activity
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


8491


225028

Ensembl


ENSG00000011566


ENSMUSG00000024242

UniProt


Q8IVH8


Q99JP0

RefSeq (mRNA)


NM_001270425 NM_003618


NM_001081357 NM_001290345 NM_001360278

RefSeq (protein)


NP_001257354 NP_003609


NP_001277274 NP_001347207

Location (UCSC)

Chr 2: 39.25 – 39.44 Mb

Chr 17: 80.58 – 80.73 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Mitogen-activated protein kinase kinase kinase kinase 3 is a protein that in humans is encoded by the MAP4K3 gene. ^[5]

Function

This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000011566 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024242 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Mitogen-activated protein kinase kinase kinase kinase 3". Retrieved 2017-09-22.

Lam D, Dickens D, Reid EB, Loh SH, Moisoi N, Martins LM (2009). "MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins". Proc. Natl. Acad. Sci. U.S.A. 106 (29): 11978–83. Bibcode:2009PNAS..10611978L. doi:10.1073/pnas.0900608106. PMC 2707271. PMID 19587239.
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Ichikawa S, Koller DL, Padgett LR, Lai D, Hui SL, Peacock M, Foroud T, Econs MJ (2010). "Replication of previous genome-wide association studies of bone mineral density in premenopausal American women". J. Bone Miner. Res. 25 (8): 1821–9. doi:10.1002/jbmr.62. PMC 3153352. PMID 20200978.
Yan L, Mieulet V, Burgess D, Findlay GM, Sully K, Procter J, Goris J, Janssens V, Morrice NA, Lamb RF (2010). "PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR". Mol. Cell. 37 (5): 633–42. doi:10.1016/j.molcel.2010.01.031. PMID 20227368.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.
Chuang HC, Lan JL, Chen DY, Yang CY, Chen YM, Li JP, Huang CY, Liu PE, Wang X, Tan TH (2011). "The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells". Nat. Immunol. 12 (11): 1113–8. doi:10.1038/ni.2121. PMID 21983831. S2CID 205364658.
Chen DY, Chuang HC, Lan JL, Chen YM, Hung WT, Lai KL, Tan TH (2012). "Germinal center kinase-like kinase (GLK/MAP4K3) expression is increased in adult-onset Still's disease and may act as an activity marker". BMC Med. 10: 84. doi:10.1186/1741-7015-10-84. PMC 3424974. PMID 22867055.
Schriever SC, Deutsch MJ, Adamski J, Roscher AA, Ensenauer R (2013). "Cellular signaling of amino acids towards mTORC1 activation in impaired human leucine catabolism". J. Nutr. Biochem. 24 (5): 824–31. doi:10.1016/j.jnutbio.2012.04.018. PMID 22898570.