CGAS |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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4LEW, 4KM5, 4O67, 4MKP, 4LEV, 4O68, 4O69 |
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Identifiers |
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Aliases | CGAS, C6orf150, cGAS, h-cGAS, Mab-21 domain containing 1, MB21D1, cyclic GMP-AMP synthase, Cyclic GMP-AMP synthase |
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External IDs | OMIM: 613973; MGI: 2442261; HomoloGene: 51384; GeneCards: CGAS; OMA:CGAS - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 6 (human)[1] |
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| Band | 6q13 | Start | 73,413,515 bp[1] |
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End | 73,452,297 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 9 (mouse)[2] |
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| Band | 9|9 E1 | Start | 78,337,808 bp[2] |
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End | 78,350,519 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - pancreatic ductal cell
- buccal mucosa cell
- endothelial cell
- monocyte
- bone marrow cells
- granulocyte
- blood
- lymph node
- external globus pallidus
- cardia
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| Top expressed in | - secondary oocyte
- primary oocyte
- zygote
- spermatocyte
- Paneth cell
- vas deferens
- condyle
- fossa
- conjunctival fornix
- bone marrow
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - nucleotidyltransferase activity
- nucleotide binding
- metal ion binding
- GTP binding
- transferase activity
- ATP binding
- DNA binding
- 2',3'-cyclic GMP-AMP synthase activity
- double-stranded DNA binding
- chromatin binding
- protein binding
| Cellular component | | Biological process | - immune system process
- cyclic nucleotide biosynthetic process
- cellular response to exogenous dsRNA
- innate immune response
- activation of innate immune response
- defense response to virus
- positive regulation of defense response to virus by host
- cellular response to DNA damage stimulus
- positive regulation of type I interferon production
- paracrine signaling
- positive regulation of cellular senescence
- positive regulation of cGMP-mediated signaling
- positive regulation of cAMP-mediated signaling
- regulation of immunoglobulin production
- determination of adult lifespan
- regulation of type I interferon production
- regulation of immune response
- regulation of T cell activation
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 6: 73.41 – 73.45 Mb | Chr 9: 78.34 – 78.35 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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