METTL2B

Protein-coding gene in the species Homo sapiens
METTL2B
Identifiers
AliasesMETTL2B, METL, METTL2, METTL2A, PSENIP1, methyltransferase like 2B, methyltransferase 2B, methylcytidine
External IDsOMIM: 607846; MGI: 1289171; HomoloGene: 130696; GeneCards: METTL2B; OMA:METTL2B - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for METTL2B
Genomic location for METTL2B
Band7q32.1Start128,476,729 bp[1]
End128,506,602 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for METTL2B
Genomic location for METTL2B
Band11 E1|11 68.61 cMStart105,017,251 bp[2]
End105,031,220 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • epithelium of colon

  • cerebellar vermis

  • islet of Langerhans

  • quadriceps femoris muscle

  • skeletal muscle tissue

  • gonad

  • endometrium

  • tonsil

  • stromal cell of endometrium

  • muscle of thigh
Top expressed in
  • otic vesicle

  • hand

  • spermatocyte

  • tail of embryo

  • epiblast

  • Rostral migratory stream

  • abdominal wall

  • primitive streak

  • embryo

  • ventricular zone
More reference expression data
BioGPS
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

55798

52686

Ensembl

ENSG00000165055

ENSMUSG00000020691

UniProt

Q6P1Q9

Q8BMK1

RefSeq (mRNA)

NM_018396

NM_172567

RefSeq (protein)

NP_060866

NP_766155

Location (UCSC)Chr 7: 128.48 – 128.51 MbChr 11: 105.02 – 105.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Methyltransferase-like protein 2B is an enzyme that in humans is encoded by the METTL2B gene.[5][6]

This gene is a member of a family of methyltransferases that share homology with, but are distinct from, the UbiE family of methyltransferases. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165055 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020691 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhang SX, Guo Y, Boulianne GL (Dec 2001). "Identification of a novel family of putative methyltransferases that interact with human and Drosophila presenilins". Gene. 280 (1–2): 135–44. doi:10.1016/S0378-1119(01)00770-3. PMID 11738826.
  6. ^ a b "Entrez Gene: METTL2B methyltransferase like 2B".

Further reading

  • Zody MC, Garber M, Adams DJ, et al. (2006). "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage". Nature. 440 (7087): 1045–9. Bibcode:2006Natur.440.1045Z. doi:10.1038/nature04689. PMC 2610434. PMID 16625196.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.


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