Protein-coding gene in the species Homo sapiens
MRPS2 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | MRPS2, MRP-S2, S2mt, CGI-91, mitochondrial ribosomal protein S2, COXPD36 |
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External IDs | OMIM: 611971; MGI: 2153089; HomoloGene: 99837; GeneCards: MRPS2; OMA:MRPS2 - orthologs |
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Gene location (Human) |
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![Chromosome 9 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/d/de/Ideogram_human_chromosome_9.svg/300px-Ideogram_human_chromosome_9.svg.png) | Chr. | Chromosome 9 (human)[1] |
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| Band | 9q34.3 | Start | 135,499,965 bp[1] |
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End | 135,505,141 bp[1] |
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Gene location (Mouse) |
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![Chromosome 2 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/b/bb/Ideogram_house_mouse_chromosome_2.svg/260px-Ideogram_house_mouse_chromosome_2.svg.png) | Chr. | Chromosome 2 (mouse)[2] |
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| Band | 2|2 A3 | Start | 28,358,078 bp[2] |
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End | 28,361,190 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - apex of heart
- right adrenal gland
- right adrenal cortex
- mucosa of transverse colon
- right lobe of liver
- left adrenal gland
- right uterine tube
- gastrocnemius muscle
- left adrenal cortex
- left ventricle
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| Top expressed in | - primitive streak
- abdominal wall
- mandibular prominence
- maxillary prominence
- tail of embryo
- endocardial cushion
- epiblast
- migratory enteric neural crest cell
- genital tubercle
- proximal tubule
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - structural constituent of ribosome
| Cellular component | - small ribosomal subunit
- ribosome
- intracellular anatomical structure
- mitochondrion
- mitochondrial inner membrane
- mitochondrial small ribosomal subunit
| Biological process | - protein biosynthesis
- mitochondrial translation
- mitochondrial translational elongation
- mitochondrial translational termination
- mitochondrial ribosome assembly
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 9: 135.5 – 135.51 Mb | Chr 2: 28.36 – 28.36 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Mitochondrial ribosomal protein S2 (MRPS2), otherwise known as uS2m, is a protein that in humans is encoded by the MRPS2 gene. [5]
Function
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S2 family. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012].
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000122140 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035772 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Mitochondrial ribosomal protein S2". Retrieved 2018-02-11.
Further reading
External links
- Overview of all the structural information available in the PDB for UniProt: Q9Y399 (Human 28S ribosomal protein S2, mitochondrial (MRPS2)) at the PDBe-KB.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.