NIF3L1

Protein-coding gene in the species Homo sapiens

NIF3L1
Identifiers
AliasesNIF3L1, ALS2CR1, CALS-7, MDS015, NGG1 interacting factor 3 like 1
External IDsOMIM: 605778; MGI: 1929485; HomoloGene: 5881; GeneCards: NIF3L1; OMA:NIF3L1 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for NIF3L1
Genomic location for NIF3L1
Band2q33.1Start200,889,327 bp[1]
End200,903,938 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for NIF3L1
Genomic location for NIF3L1
Band1|1 C1.3Start58,484,310 bp[2]
End58,520,975 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • gonad

  • rectum

  • islet of Langerhans

  • Achilles tendon

  • testicle

  • Skeletal muscle tissue of biceps brachii

  • palpebral conjunctiva

  • middle temporal gyrus

  • Skeletal muscle tissue of rectus abdominis
Top expressed in
  • otic vesicle

  • otic placode

  • epiblast

  • lens

  • primitive streak

  • embryo

  • facial motor nucleus

  • saccule

  • ventricular zone

  • medial ganglionic eminence
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transcription factor binding
  • protein binding
  • identical protein binding
Cellular component
  • cytoplasm
  • nucleus
  • mitochondrion
Biological process
  • positive regulation of transcription, DNA-templated
  • negative regulation of nucleic acid-templated transcription
  • neuron differentiation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

60491

65102

Ensembl

ENSG00000196290

ENSMUSG00000026036

UniProt

Q9GZT8

Q9EQ80

RefSeq (mRNA)
NM_001136039
NM_001142355
NM_001142356
NM_021824
NM_001369441

NM_001369442
NM_001369443
NM_001369444
NM_001369445

NM_022988

RefSeq (protein)
NP_001129511
NP_001135827
NP_001135828
NP_068596
NP_001356370

NP_001356371
NP_001356372
NP_001356373
NP_001356374

NP_075364

Location (UCSC)Chr 2: 200.89 – 200.9 MbChr 1: 58.48 – 58.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

NIF3-like protein 1 is a protein that in humans is encoded by the NIF3L1 gene.[5][6][7][8]

Interactions

NIF3L1 has been shown to interact with COPS2.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196290 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026036 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tascou S, Uedelhoven J, Dixkens C, Nayernia K, Engel W, Burfeind P (Jan 2001). "Isolation and characterization of a novel human gene, NIF3L1, and its mouse ortholog, Nif3l1, highly conserved from bacteria to mammals". Cytogenetics and Cell Genetics. 90 (3–4): 330–6. doi:10.1159/000056799. PMID 11124544. S2CID 23200951.
  6. ^ Hadano S, Yanagisawa Y, Skaug J, Fichter K, Nasir J, Martindale D, Koop BF, Scherer SW, Nicholson DW, Rouleau GA, Ikeda J, Hayden MR (Jan 2001). "Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2". Genomics. 71 (2): 200–13. doi:10.1006/geno.2000.6392. PMID 11161814.
  7. ^ a b Akiyama H, Fujisawa N, Tashiro Y, Takanabe N, Sugiyama A, Tashiro F (Mar 2003). "The role of transcriptional corepressor Nif3l1 in early stage of neural differentiation via cooperation with Trip15/CSN2". The Journal of Biological Chemistry. 278 (12): 10752–62. doi:10.1074/jbc.M209856200. PMID 12522100.
  8. ^ "Entrez Gene: NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. pombe)".

Further reading

  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Tascou S, Kang TW, Trappe R, Engel W, Burfeind P (Sep 2003). "Identification and characterization of NIF3L1 BP1, a novel cytoplasmic interaction partner of the NIF3L1 protein". Biochemical and Biophysical Research Communications. 309 (2): 440–8. doi:10.1016/j.bbrc.2003.07.008. PMID 12951069.
  • Merla G, Howald C, Antonarakis SE, Reymond A (Jul 2004). "The subcellular localization of the ChoRE-binding protein, encoded by the Williams-Beuren syndrome critical region gene 14, is regulated by 14-3-3". Human Molecular Genetics. 13 (14): 1505–14. doi:10.1093/hmg/ddh163. PMID 15163635.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.


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