NPDC1

Protein-coding gene in the species Homo sapiens
NPDC1
Identifiers
AliasesNPDC1, CAB, CAB-, CAB-1, CAB1, NPDC-1, neural proliferation, differentiation and control, 1, neural proliferation, differentiation and control 1
External IDsOMIM: 605798; MGI: 1099802; HomoloGene: 32050; GeneCards: NPDC1; OMA:NPDC1 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for NPDC1
Genomic location for NPDC1
Band9q34.3Start137,039,463 bp[1]
End137,046,179 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for NPDC1
Genomic location for NPDC1
Band2|2 A3Start25,289,363 bp[2]
End25,299,506 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • pituitary gland

  • anterior pituitary

  • right frontal lobe

  • prostate

  • Brodmann area 9

  • cerebellar vermis

  • primary visual cortex

  • hypothalamus

  • right uterine tube
Top expressed in
  • dentate gyrus of hippocampal formation granule cell

  • primary visual cortex

  • superior frontal gyrus

  • cerebellar cortex

  • perirhinal cortex

  • entorhinal cortex

  • CA3 field

  • superior colliculus

  • ventromedial nucleus

  • primary motor cortex
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • membrane
  • integral component of membrane
  • plasma membrane
Biological process
  • regulation of immune response
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

56654

18146

Ensembl

ENSG00000107281

ENSMUSG00000015094

UniProt

Q9NQX5

Q64322

RefSeq (mRNA)

NM_015392

NM_008721

RefSeq (protein)

NP_056207

NP_032747

Location (UCSC)Chr 9: 137.04 – 137.05 MbChr 2: 25.29 – 25.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neural proliferation differentiation and control protein 1 is a protein that in humans is encoded by the NPDC1 gene.[5][6]

Interactions

NPDC1 has been shown to interact with E2F1.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000107281 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015094 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Qu X, Zhang C, Zhai Y, Xing G, Wei H, Yu Y, Wu S, He F (March 2001). "Characterization and tissue expression of a novel human gene npdc1". Gene. 264 (1): 37–44. doi:10.1016/S0378-1119(01)00324-9. PMID 11245976.
  6. ^ "Entrez Gene: NPDC1 neural proliferation, differentiation and control, 1".
  7. ^ Sansal I, Dupont E, Toru D, Evrard C, Rouget P (October 2000). "NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity". Oncogene. 19 (43): 5000–9. doi:10.1038/sj.onc.1203843. PMID 11042687.

Further reading

  • Dupont E, Sansal I, Toru D, Evrard C, Rouget P (1997). "[Identification of NPDC-1, gene involved in the control of proliferation and differentiation of neural and glial precursors]". C. R. Séances Soc. Biol. Fil. 191 (1): 95–104. PMID 9181131.
  • Galiana E, Vernier P, Dupont E, Evrard C, Rouget P (1995). "Identification of a neural-specific cDNA, NPDC-1, able to down-regulate cell proliferation and to suppress transformation". Proc. Natl. Acad. Sci. U.S.A. 92 (5): 1560–4. Bibcode:1995PNAS...92.1560G. doi:10.1073/pnas.92.5.1560. PMC 42559. PMID 7878019.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Iwasaki K, Toyonaga R (2000). "The Rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission". EMBO J. 19 (17): 4806–16. doi:10.1093/emboj/19.17.4806. PMC 302062. PMID 10970871.
  • Sansal I, Dupont E, Toru D, Evrard C, Rouget P (2000). "NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity". Oncogene. 19 (43): 5000–9. doi:10.1038/sj.onc.1203843. PMID 11042687.
  • Spencer ML, Theodosiou M, Noonan DJ (2004). "NPDC-1, a novel regulator of neuronal proliferation, is degraded by the ubiquitin/proteasome system through a PEST degradation motif". J. Biol. Chem. 279 (35): 37069–78. doi:10.1074/jbc.M402507200. PMID 15229225.
  • Evrard C, Caron S, Rouget P (2004). "Functional analysis of the NPDC-1 gene". Gene. 343 (1): 153–63. doi:10.1016/j.gene.2004.08.020. PMID 15563841.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.


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